Abstract |
Calicivirus infection of adult rabbits induces the so-called rabbit haemorrhagic disease (RHD) that kills 90% or more of the infected animals; in contrast, young rabbits (up to 8-week-old animals) are resistant to the same infectious agent. We report that calicivirus inoculation of young rabbits induced moderate titres of antiviral antibodies. When these rabbits reached adulthood, a second calicivirus inoculation resulted in resistance to RHD and boosting of antibody titres in half of the rabbits. Adoptive transfer of sera from calicivirus-infected young rabbits to naïve adult rabbits conferred resistance to RHD. We conclude that calicivirus infection of young rabbits induces specific anti-calicivirus antibodies that will protect them from RHD when they reach adulthood.
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Authors | P G Ferreira, M Dinís, A Costa-E-Silva, A P Aguas |
Journal | Veterinary immunology and immunopathology
(Vet Immunol Immunopathol)
Vol. 121
Issue 3-4
Pg. 364-9
(Feb 15 2008)
ISSN: 0165-2427 [Print] Netherlands |
PMID | 17980918
(Publication Type: Journal Article, Research Support, Non-U.S. Gov't)
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Chemical References |
- Antibodies, Viral
- Antigens, Viral
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Topics |
- Adoptive Transfer
(veterinary)
- Animals
- Antibodies, Viral
(blood)
- Antigens, Viral
(blood)
- Caliciviridae Infections
(immunology, prevention & control, veterinary, virology)
- Enzyme-Linked Immunosorbent Assay
(veterinary)
- Hemorrhagic Disease Virus, Rabbit
(immunology)
- Rabbits
(immunology)
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