Abstract | BACKGROUND: METHODS AND RESULTS: The group of patients comprised of 60 subjects, 218 healthy unrelated subjects were included in the cotrol group. In both groups genotypes of CYP2D6 and CYP2C19 were analyzed. There were significantly fewer extensive metabolizers of CYP2D6 in the patient group comparison with healthy control subjects (25.0% vs. 49.8%) while the proportion of intermediate metabolizers was significantly higher than in helthy population (58.3% vs. 38.5%). We also observed more poor metabolizers than in control group (13.3% vs. 6.8%), but the difference did not reach level of statistical significance probably due to low number of subjects. The distribution of either ultrarapid metabolizers of CYP2D6 or deficient alleles of CYP2C19 was similar in both groups. CONCLUSIONS: Clinically apparent alteration of drug effects are often caused by partial or complete deficit of CYP2D6 activity. Our results confirm the importance of CYP2D6 polymorphisms on the efficycy and safety of pharmacotherapy.
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Authors | O Slanar, M Drazd'áková, K Babiárová, K Pechandová, H Buzková, F Perlík, T Zima |
Journal | Casopis lekaru ceskych
(Cas Lek Cesk)
Vol. 146
Issue 9
Pg. 708-11
( 2007)
ISSN: 0008-7335 [Print] Czech Republic |
Vernacular Title | Genotypizace cytochromu P450 2D6 a 2C19. |
PMID | 17966194
(Publication Type: Journal Article)
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Chemical References |
- Mixed Function Oxygenases
- Aryl Hydrocarbon Hydroxylases
- CYP2C19 protein, human
- Cytochrome P-450 CYP2C19
- Cytochrome P-450 CYP2D6
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Topics |
- Aryl Hydrocarbon Hydroxylases
(genetics)
- Cytochrome P-450 CYP2C19
- Cytochrome P-450 CYP2D6
(genetics)
- Female
- Genotype
- Humans
- Male
- Mixed Function Oxygenases
(genetics)
- Pharmacogenetics
- Pharmacokinetics
- Polymorphism, Genetic
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