[ACE-inhibitor induced angioedema].

Abstract

ACE-inhibitor induced angioedema is a non-allergic drug-related side effect. Inhibited bradykinin degradation leads to an unphysiological enhanced bradykinin plasma level with vascular leakage and, consequently, to angioedema. ACE-inhibitor induced angioedema develop rapidly in the head and neck region. Typical sites of manifestation are lips, tongue, and larynx. Novel pharmacotherapies may allow a causal treatment of the ACE-inhibitor induced angioedema in the future.

• Authors: M Bas, T K Hoffmann, G Kojda, H Bier
• Journal: Laryngo- rhino- otologie (Laryngorhinootologie) Vol. 86 Issue 11 Pg. 804-8, quiz 809-13 (Nov 2007) ISSN: 0935-8943 [Print] Germany
• Vernacular Title: Das ACE-Hemmer-induzierte Angioödem.
• PMID: 17966084 (Publication Type: Journal Article, Review)

Chemical References

• Adrenal Cortex Hormones
• Angiotensin-Converting Enzyme Inhibitors
• Bradykinin Receptor Antagonists
• Histamine Antagonists
• icatibant
• Bradykinin

Topics

• Adrenal Cortex Hormones (therapeutic use)
• Algorithms
• Angioedema (blood, chemically induced, diagnosis, diagnostic imaging, drug therapy, physiopathology, therapy)
• Angioedemas, Hereditary (diagnosis)
• Angiotensin-Converting Enzyme Inhibitors (adverse effects, pharmacology)
• Bradykinin (analogs & derivatives, blood, physiology, therapeutic use)
• Bradykinin Receptor Antagonists
• Forecasting
• Histamine Antagonists (therapeutic use)
• Humans
• Laryngeal Edema (chemically induced, diagnosis)
• Laryngoscopy
• Magnetic Resonance Imaging
• Time Factors
• Tomography, X-Ray Computed