Resolution of superior oblique myokymia with memantine.

Abstract

We describe a novel treatment of superior oblique myokymia. A 40-year-old woman was treated with gabapentin for this disorder with partial success and reported significant side effects including loss of libido and weight gain. After a drug holiday, memantine therapy was initiated resulting in a substantial improvement in her symptoms with far fewer side effects and stability on long-term maintenance therapy.

• Authors: Saurabh Jain, Shegufta J Farooq, Irene Gottlob
• Journal: Journal of AAPOS : the official publication of the American Association for Pediatric Ophthalmology and Strabismus (J AAPOS) Vol. 12 Issue 1 Pg. 87-8 (Feb 2008) ISSN: 1528-3933 [Electronic] United States
• PMID: 17964207 (Publication Type: Case Reports, Journal Article, Research Support, Non-U.S. Gov't)

Chemical References

• Dopamine Agents
• Memantine

Topics

• Administration, Oral
• Adult
• Diagnosis, Differential
• Dopamine Agents (administration & dosage, therapeutic use)
• Dose-Response Relationship, Drug
• Eye Movements
• Female
• Follow-Up Studies
• Humans
• Magnetic Resonance Imaging
• Memantine (administration & dosage, therapeutic use)
• Myokymia (diagnosis, drug therapy, physiopathology)
• Ocular Motility Disorders (diagnosis, drug therapy, physiopathology)
• Oculomotor Muscles (physiopathology)