Abstract | BACKGROUND AND OBJECTIVES: METHODS: Full-thickness wounds measuring 1.5 cm square were created on the dorsum of Yorkshire pigs and were enclosed in polyurethane wound chambers. Amitriptyline was applied daily at various concentrations. Bupivacaine (0.5%) or normal saline were used as controls. Daily wound serum levels were obtained and the level of amitriptyline and nortriptyline obtained. Pictures were taken daily and the wound surface analyzed for contraction. Cross-sectional, full-thickness skin biopsies were obtained at days 2, 8 and 10 and evaluated microscopically for re-epithelialization, inflammation, and necrosis. RESULTS: CONCLUSION:
Amitriptyline at the concentrations of 0.0625% and 0.125% applied daily via chambers covering wounds in a full-thickness pig excision model has no overt toxic effect on wound healing as measured by wound contraction and histological assessment.
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Authors | Bohdan Pomahac, Bara Zuhaili, Yusef Kudsi, Oliver Bleiziffer, Patrik Velander, Elof Eriksson, Peter Gerner |
Journal | Regional anesthesia and pain medicine
(Reg Anesth Pain Med)
2007 Sep-Oct
Vol. 32
Issue 5
Pg. 377-81
ISSN: 1098-7339 [Print] England |
PMID | 17961834
(Publication Type: Journal Article, Research Support, U.S. Gov't, Non-P.H.S.)
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Chemical References |
- Anesthetics, Local
- Antidepressive Agents, Tricyclic
- Amitriptyline
- Nortriptyline
- Bupivacaine
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Topics |
- Amitriptyline
(administration & dosage, adverse effects, pharmacokinetics)
- Anesthetics, Local
(administration & dosage, therapeutic use)
- Animals
- Antidepressive Agents, Tricyclic
(administration & dosage, adverse effects, pharmacokinetics)
- Body Fluids
(metabolism)
- Bupivacaine
(administration & dosage, therapeutic use)
- Epithelial Cells
(pathology)
- Inflammation
(pathology)
- Necrosis
- Nortriptyline
(metabolism)
- Pain
(etiology, psychology)
- Pain Measurement
(drug effects)
- Swine
- Wound Healing
(drug effects)
- Wounds and Injuries
(drug therapy, metabolism, pathology)
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