Abstract | BACKGROUND: METHODS: A population-based case-control study of stroke among women aged 15-49 identified 224 cases of first ischemic stroke (47.3% African-American) and 211 age-matched control subjects (43.1% African-American). Neuroserpin single nucleotide polymorphisms (SNPs) chosen through HapMap were genotyped in the study population and assessed for association with stroke. RESULTS: Of the five SNPs analyzed, the A allele (frequency; Caucasian = 0.56, African-American = 0.42) of SNP rs6797312 located in intron 1 was associated with stroke in an age-adjusted dominant model (AA and AT vs. TT) among Caucasians (OR = 2.05, p = 0.023) but not African-Americans (OR = 0.71, p = 0.387). Models adjusting for other risk factors strengthened the association. Race-specific haplotype analyses, inclusive of SNP rs6797312, again demonstrated significant associations with stroke among Caucasians only. CONCLUSION:
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Authors | John W Cole, Adam C Naj, Jeffrey R O'Connell, Oscar C Stine, John D Sorkin, Marcella A Wozniak, Barney J Stern, Manuel Yepes, Daniel A Lawrence, Laurie J Reinhart, Dudley K Strickland, Braxton D Mitchell, Steven J Kittner |
Journal | BMC neurology
(BMC Neurol)
Vol. 7
Pg. 37
(Oct 25 2007)
ISSN: 1471-2377 [Electronic] England |
PMID | 17961231
(Publication Type: Journal Article, Research Support, N.I.H., Extramural, Research Support, Non-U.S. Gov't, Research Support, U.S. Gov't, Non-P.H.S.)
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Chemical References |
- Neuropeptides
- Serpins
- neuroserpin
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Topics |
- Adolescent
- Adult
- Black People
- Case-Control Studies
- Community Health Planning
- Female
- Gene Frequency
- Genetic Predisposition to Disease
- Genotype
- Humans
- Linkage Disequilibrium
- Middle Aged
- Neuropeptides
(genetics)
- Polymorphism, Single Nucleotide
(genetics)
- Risk Factors
- Serpins
(genetics)
- Stroke
(epidemiology, genetics)
- White People
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