Nitric oxide, ischaemia and brain inflammation.

Abstract	Cerebral ischaemia results in the activation of three isoforms of NOS (nitric oxide synthase) that contribute to the development of and recovery from stroke pathology. This review discusses, in particular, the role of the transcriptionally activated NOS-2 (inducible NOS) isoform and summarizes the outcomes of experimental stroke studies with regard to the therapeutic utility of nitric oxide donors and NOS inhibitors.
Authors	S Murphy, C L Gibson
Journal	Biochemical Society transactions (Biochem Soc Trans) Vol. 35 Issue Pt 5 Pg. 1133-7 (Nov 2007) ISSN: 0300-5127 [Print] England
PMID	17956295 (Publication Type: Journal Article, Research Support, N.I.H., Extramural, Review)
Chemical References	Nitric Oxide Donors Nitric Oxide Nitric Oxide Synthase
Topics	Brain Ischemia (physiopathology) Enzyme Activation Humans Inflammation (physiopathology) Nitric Oxide (physiology) Nitric Oxide Donors (pharmacology) Nitric Oxide Synthase (metabolism)

Join CureHunter, for free Research Interface BASIC access!

Take advantage of free CureHunter research engine access to explore the best drug and treatment options for any disease. Find out why thousands of doctors, pharma researchers and patient activists around the world use CureHunter every day.

Realize the full power of the drug-disease research graph!