Triamcinolone acetonide as an adjuvant in the surgical treatment of retinal detachment with proliferative vitreoretinopathy.

Abstract

BACKGROUND AND OBJECTIVE:

To report the efficacy of intravitreal triamcinolone acetonide as an adjuvant in the surgical management of cases with advanced proliferative vitreoretinopathy (PVR).

PATIENTS AND METHODS:

Patients with complicated rhegmatogenous retinal detachment and PVR grade C2 or greater were recruited for this interventional, noncomparative, prospective study. All patients underwent three-port pars plana vitrectomy, membrane peeling, laser photocoagulation, and silicone oil injection to reattach the retina followed by 0.1 mL (4 mg) of triamcinolone acetonide injected through the pars plana into the silicone oil. All patients had supplemental laser therapy around retinal breaks and retinectomy edges at 1 to 2 weeks postoperatively.

RESULTS:

Patients included 15 males and 9 females, with an average age of 53.6 years (range: 15 to 84 years) and PVR grade C2 to PVR C9. The mean follow-up period was 11.0 months (range: 3 to 26 months). Twenty-one (87.5%) patients had attached retinas at the final followup visit. Visual acuity improved in all patients following surgery (P < .05).

CONCLUSION:

Triamcinolone acetonide may have potential as an adjuvant in the treatment of retinal detachment with PVR. Further research is required to evaluate the efficacy of this adjuvant treatment.

• Authors: Rizwan A Cheema, Gholam A Peyman, Ting Fang, Andrew Jones, Andrew D Lukaris, Kim Lim
• Journal: Ophthalmic surgery, lasers & imaging : the official journal of the International Society for Imaging in the Eye (Ophthalmic Surg Lasers Imaging) 2007 Sep-Oct Vol. 38 Issue 5 Pg. 365-70 ISSN: 1542-8877 [Print] United States
• PMID: 17955840 (Publication Type: Journal Article)

Chemical References

• Glucocorticoids
• Triamcinolone Acetonide

Topics

• Adolescent
• Aged
• Aged, 80 and over
• Chemotherapy, Adjuvant
• Female
• Follow-Up Studies
• Glucocorticoids (administration & dosage, therapeutic use)
• Humans
• Injections
• Male
• Middle Aged
• Prospective Studies
• Retinal Detachment (complications, etiology, physiopathology, surgery)
• Retinal Perforations (complications)
• Severity of Illness Index
• Treatment Outcome
• Triamcinolone Acetonide (administration & dosage, therapeutic use)
• Visual Acuity
• Vitrectomy
• Vitreoretinopathy, Proliferative (complications, physiopathology, surgery)
• Vitreous Body