Abstract | OBJECTIVE: METHODS: We studied 26 consecutive psychiatric inpatients (22 women and 4 men) receiving the aforementioned medications, who were referred to us for a consultation. They ranged in age from 19 to 79 years and had a mean body mass index (SEM) of 32.35 +/- 1.26 kg/m2. Between 8 AM and 9 AM, blood samples were collected for 17-hydroxyprogesterone, 17-hydroxypregnenolone, androstenedione, dehydroepiandrosterone ( DHEA), DHEA sulfate, 11-deoxycortisol, luteinizing hormone and follicle-stimulating hormone (in reproductive age women), estrone, estradiol (in reproductive age women), free testosterone (in women), deoxycorticosterone, and sex hormone-binding globulin (SHBG), which were measured by radioimmunoassay, after chromatography if necessary. For intact, premenopausal women, measurement of the abnormal steroid metabolite or SHBG level was repeated during prednisone therapy (5 mg at bedtime) to document the likely adrenal origin of the abnormality. Men, women who had undergone bilateral oophorectomy, and postmenopausal women had hyperandrogenism of adrenal origin by default. Clinical features included central obesity, acanthosis, hirsutism, alopecia, type 2 diabetes mellitus, and oligomenorrhea. RESULTS: CONCLUSION:
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Authors | Gül Bahtiyar, Karolina Weiss, Alan S Sacerdote |
Journal | Endocrine practice : official journal of the American College of Endocrinology and the American Association of Clinical Endocrinologists
(Endocr Pract)
Vol. 13
Issue 6
Pg. 601-8
(Oct 2007)
ISSN: 1934-2403 [Electronic] United States |
PMID | 17954415
(Publication Type: Journal Article)
|
Chemical References |
- Antipsychotic Agents
- Endocrine Disruptors
- Hypoglycemic Agents
- Thiazolidinediones
- Rosiglitazone
- Estrone
- Testosterone
- Dehydroepiandrosterone
- Estradiol
- Valproic Acid
- 17-alpha-Hydroxyprogesterone
- Luteinizing Hormone
- Follicle Stimulating Hormone
- Metformin
- Cortodoxone
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Topics |
- 17-alpha-Hydroxyprogesterone
(blood)
- Adolescent
- Adrenal Glands
(drug effects, metabolism, pathology)
- Adult
- Aged
- Antipsychotic Agents
(adverse effects, therapeutic use)
- Cortodoxone
(blood)
- Dehydroepiandrosterone
(blood)
- Endocrine Disruptors
(adverse effects)
- Estradiol
(blood)
- Estrone
(blood)
- Female
- Follicle Stimulating Hormone
(blood)
- Humans
- Hyperandrogenism
(blood, chemically induced, prevention & control)
- Hypoglycemic Agents
(therapeutic use)
- Insulin Resistance
- Luteinizing Hormone
(blood)
- Male
- Metformin
(therapeutic use)
- Middle Aged
- Radioimmunoassay
- Rosiglitazone
- Testosterone
(blood)
- Thiazolidinediones
(therapeutic use)
- Valproic Acid
(adverse effects, therapeutic use)
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