Abstract |
Excimer laser treatment for psoriasis has been associated with good results at a lower cumulative dose than narrowband ultraviolet (UV)B protocols. To examine the clinical performance of a new targeted UVB lamp (290-320 nm; BClear) in the treatment of plaque-type psoriasis, 28 consecutive patients attending a dermatology service were treated twice weekly with the UVB lamp for 6-18 sessions (median 10). UV doses were based on multiples of a predetermined minimal erythema dose (MED). MEDs ranged from 150 to 350 mJ/cm2; maximal dose was 8 MED. Mean cumulative fluence until remission was 12.63 J/cm2. The Psoriasis Severity Index (PSI) was measured every 2 weeks for 16 weeks. Mean PSI improvement during treatment peaked at 73% after 6 weeks, and declined to 63% at 16 weeks. At that point, 36% of the patients had a > 75% improvement in PSI, and 21% showed complete clearance. Targeted radiation with the UVB lamp is effective for the treatment of plaque-type psoriasis, requiring as few as six sessions and achieving moderately long remission. As treatment is selectively directed toward lesioned skin, normal surrounding skin is spared unnecessary radiation exposure.
|
Authors | M Lapidoth, M Adatto, M David |
Journal | Clinical and experimental dermatology
(Clin Exp Dermatol)
Vol. 32
Issue 6
Pg. 642-5
(Nov 2007)
ISSN: 0307-6938 [Print] England |
PMID | 17953632
(Publication Type: Evaluation Study, Journal Article)
|
Topics |
- Adult
- Aged
- Erythema
(etiology)
- Female
- Follow-Up Studies
- Humans
- Male
- Middle Aged
- Psoriasis
(pathology, radiotherapy)
- Radiation Injuries
(etiology)
- Radiotherapy Dosage
- Severity of Illness Index
- Treatment Outcome
- Ultraviolet Therapy
(adverse effects, instrumentation, methods)
|