Targeted UVB phototherapy for psoriasis: a preliminary study.

Excimer laser treatment for psoriasis has been associated with good results at a lower cumulative dose than narrowband ultraviolet (UV)B protocols. To examine the clinical performance of a new targeted UVB lamp (290-320 nm; BClear) in the treatment of plaque-type psoriasis, 28 consecutive patients attending a dermatology service were treated twice weekly with the UVB lamp for 6-18 sessions (median 10). UV doses were based on multiples of a predetermined minimal erythema dose (MED). MEDs ranged from 150 to 350 mJ/cm2; maximal dose was 8 MED. Mean cumulative fluence until remission was 12.63 J/cm2. The Psoriasis Severity Index (PSI) was measured every 2 weeks for 16 weeks. Mean PSI improvement during treatment peaked at 73% after 6 weeks, and declined to 63% at 16 weeks. At that point, 36% of the patients had a > 75% improvement in PSI, and 21% showed complete clearance. Targeted radiation with the UVB lamp is effective for the treatment of plaque-type psoriasis, requiring as few as six sessions and achieving moderately long remission. As treatment is selectively directed toward lesioned skin, normal surrounding skin is spared unnecessary radiation exposure.
AuthorsM Lapidoth, M Adatto, M David
JournalClinical and experimental dermatology (Clin Exp Dermatol) Vol. 32 Issue 6 Pg. 642-5 (Nov 2007) ISSN: 0307-6938 [Print] England
PMID17953632 (Publication Type: Evaluation Studies, Journal Article)
  • Adult
  • Aged
  • Erythema (etiology)
  • Female
  • Follow-Up Studies
  • Humans
  • Male
  • Middle Aged
  • Psoriasis (pathology, radiotherapy)
  • Radiation Injuries (etiology)
  • Radiotherapy Dosage
  • Severity of Illness Index
  • Treatment Outcome
  • Ultraviolet Therapy (adverse effects, instrumentation, methods)

Join CureHunter, for free Research Interface BASIC access!

Take advantage of free CureHunter research engine access to explore the best drug and treatment options for any disease. Find out why thousands of doctors, pharma researchers and patient activists around the world use CureHunter every day.
Realize the full power of the drug-disease research network!

Choose Username:
Verify Password: