[The irradiation consequencees of animals with alloxan-induced diabetes].

Abstract

The effects of external acute irradiation at dose 1.0 Gy on biologic, haematologic and metabolic changes in blood of alloxan-induced diabetic rats were studied. It was found that the deterioration of diabetic animals occurs in different terms after irradiation exposure, resulting in considerable body weight decrease, well-marked hyperglycemia, abrupt falling of leukocytic system parameters, intensification energetic processes of extant lymphocytes, imbalance of lipid metabolism and thyroid state, as well as significant inhibition of 5'-deiodinase activity in liver tissue.

• Authors: E F Konoplia, G G Vereshchako, G A Gorokh, E V Andronov, O V Luk'ianenko
• Journal: Radiatsionnaia biologiia, radioecologiia (Radiats Biol Radioecol) 2007 Jul-Aug Vol. 47 Issue 4 Pg. 476-80 ISSN: 0869-8031 [Print] Russia (Federation)
• PMID: 17953435 (Publication Type: English Abstract, Journal Article)

Chemical References

• Lipids
• Triiodothyronine
• Alloxan
• Iodide Peroxidase
• Thyroxine

Topics

• Alloxan (toxicity)
• Animals
• Body Weight (radiation effects)
• Diabetes Mellitus, Experimental (complications)
• Gamma Rays (adverse effects)
• Iodide Peroxidase (antagonists & inhibitors, radiation effects)
• Leukocyte Count
• Leukocytes (radiation effects)
• Lipid Metabolism (radiation effects)
• Lipids (blood)
• Male
• Radiation Injuries, Experimental (blood, complications, metabolism)
• Rats
• Rats, Inbred Strains
• Thyroid Gland (radiation effects)
• Thyroxine (blood)
• Triiodothyronine (blood)