Ergotism unresponsive to multiple therapeutic modalities, including sodium nitroprusside, resulting in limb loss.

Abstract	Unlike epidemics in past centuries, patients suffering from peripheral vascular ischemia related to ergotism now rarely lose a limb because of vasodilator therapies. We report a patient with ischemia from ergotamine tartrate who failed to recover with medical therapy, resulting in limb amputation.
Authors	Khrongwong Musikatavorn, Suchai Suteparuk
Journal	Clinical toxicology (Philadelphia, Pa.) (Clin Toxicol (Phila)) Vol. 46 Issue 2 Pg. 157-8 (Feb 2008) ISSN: 1556-3650 [Print] England
PMID	17952750 (Publication Type: Case Reports, Journal Article)
Chemical References	Vasoconstrictor Agents Nitroprusside Ergotamine
Topics	Adult Amputation, Surgical Combined Modality Therapy Ergotamine (adverse effects, therapeutic use) Ergotism (drug therapy, etiology) Foot (blood supply, pathology, surgery) Gangrene (chemically induced, drug therapy, pathology) Humans Injections, Intravenous Ischemia (chemically induced, diagnosis) Leg Male Nitroprusside (administration & dosage, therapeutic use) Pain (prevention & control) Treatment Failure Vasoconstrictor Agents (adverse effects, therapeutic use)

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