Abstract |
Immune-mediated pathways have been recognized to be of importance in the pathogenesis of chronic lymphocytic leukaemia (CLL). We assessed a broad variety of immune-related and inflammatory conditions and subsequent CLL development among 4 million adult male veterans admitted to VA hospitals. We identified 3,680 CLL cases with up to 27 years of follow-up. Using Poisson regression analyses restricted to immune-related or inflammatory conditions that occurred more than one year before CLL, we estimated relative risk (RR) and 95% confidence intervals for CLL risk. Elevated CLL risk was found among individuals with prior chronic sinusitis (RR = 1.27, 1.01-1.61). Pneumonia had a borderline (RR = 1.13, 1.00-1.27) association with CLL; the risk was further elevated (RR = 1.35, 1.07-1.72) for latency <5 years. Conversely, chronic non-rheumatic valvular heart disease was associated with 0.76-fold (0.58-0.99) decreased risk. Herpes zoster and simplex were associated with increased (RR = 1.98, 1.40-2.79) and borderline increased (RR = 1.69, 0.96-2.98) CLL risk. There was no general association between autoimmunity and CLL; however, autoimmune haemolytic anaemia was associated with 3.86-fold (1.93-7.74) elevated CLL risk. Individuals with chronic osteoarthritis and prostatitis had 1.14-fold (1.03-1.25) and 1.64-fold (1.14-2.37) elevated CLL risk. These association patterns suggest primary focus on infectious agents rather than autoantigens for future aetiologic CLL studies.
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Authors | Ola Landgren, Gloria Gridley, David Check, Neil E Caporaso, Linda Morris Brown |
Journal | British journal of haematology
(Br J Haematol)
Vol. 139
Issue 5
Pg. 791-8
(Dec 2007)
ISSN: 1365-2141 [Electronic] England |
PMID | 17941950
(Publication Type: Journal Article, Multicenter Study, Research Support, N.I.H., Intramural)
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Topics |
- Adult
- Anemia, Hemolytic, Autoimmune
(complications, epidemiology)
- Autoimmune Diseases
(complications, epidemiology)
- Chronic Disease
- Communicable Diseases
(complications, epidemiology)
- Follow-Up Studies
- Humans
- Inflammation
(complications, epidemiology)
- Leukemia, Lymphocytic, Chronic, B-Cell
(epidemiology, etiology)
- Male
- Middle Aged
- Pneumonia
(complications, epidemiology)
- Risk Factors
- Sinusitis
(complications, epidemiology)
- United States
(epidemiology)
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