Efficacy of low dose clofarabine in refractory precursor T- acute lymphoblastic leukemia.

Abstract

Refractory T-lymphoblastic leukemia in adults has a poor prognosis in patients who relapse after allogeneic stem cell transplantation, and relatively few new agents have demonstrated activity. Clofarabine is a novel nucleoside analog that has been associated with significant clinical activity in relapsed pediatric B-ALL. We used low dose clofarabine and induced a remission in a patient who relapsed in the skin and marrow after allogeneic transplant and was refractory to nelarabine and report a near complete response, suggesting significant activity for low intermittent dose clofarabine in patients with relapsed T-cell leukemias.

• Authors: Jaehyuk Choi, Francine Foss
• Journal: The Yale journal of biology and medicine (Yale J Biol Med) Vol. 79 Issue 3-4 Pg. 169-72 (Dec 2006) ISSN: 1551-4056 [Electronic] United States
• PMID: 17940627 (Publication Type: Case Reports, Journal Article)

Chemical References

• Adenine Nucleotides
• Arabinonucleosides
• nelarabine
• Clofarabine

Topics

• Adenine Nucleotides (therapeutic use)
• Adult
• Arabinonucleosides (pharmacology, therapeutic use)
• Bone Marrow Neoplasms (drug therapy, secondary)
• Clinical Trials as Topic
• Clofarabine
• Drug Administration Schedule
• Drug Resistance, Neoplasm
• Humans
• Immunophenotyping
• Leukemia-Lymphoma, Adult T-Cell (drug therapy)
• Male
• Recurrence
• Skin Neoplasms (drug therapy, secondary)
• Stem Cell Transplantation
• Transplantation, Homologous
• Treatment Outcome