Influence of carboplatin infusion on osteosarcoma blood flow.

Abstract

PURPOSE:

Herein we report that carboplatin infusion influenced tumor blood flow signal independent of the mechanical decompression induced by the artificial lymphatics system technology that was being evaluated as part of a randomized veterinary clinical trial, treating spontaneously occurring canine appendicular osteosarcoma, a tumor very similar to its human counterpart.

METHODS:

Blood flow within the central region of the tumor was recorded continuously using laser Doppler flowmetry, a real-time measurement technology. Time-averaged flow values were computed from segments taken from the recordings immediately before starting carboplatin infusion, and during infusion.

RESULTS:

Carboplatin increased the tumor blood flow signal by an additional 59 +/- 26% (mean +/- SEM; p = 0.06) over the increase induced by the decompression. The increase started within 49 +/- 46 s after the start of infusion, had a response time constant of 19 +/- 21 s and persisted throughout the infusion, ending shortly after infusion ended.

CONCLUSION:

The rapidity of the flow signal increase suggests that carboplatin may have an autonomic effect on circulation, either local or systemic. The observations identify a new action of this drug and suggest a possible mechanism to exploit therapeutically.

• Authors: Gene R DiResta, Sean W Aiken, Holly K Brown, Philip J Bergman, Ann Hohenhaus, John H Healey
• Journal: Cancer chemotherapy and pharmacology (Cancer Chemother Pharmacol) Vol. 62 Issue 3 Pg. 545-9 (Aug 2008) ISSN: 0344-5704 [Print] Germany
• PMID: 17932675 (Publication Type: Journal Article, Randomized Controlled Trial, Research Support, N.I.H., Extramural, Research Support, Non-U.S. Gov't)

Chemical References

• Antineoplastic Agents
• Carboplatin

Topics

• Animals
• Antineoplastic Agents (administration & dosage, therapeutic use)
• Bone Neoplasms (blood supply, drug therapy, veterinary)
• Carboplatin (administration & dosage, therapeutic use)
• Dog Diseases (drug therapy)
• Dogs
• Drug Delivery Systems
• Electrocardiography
• Infusions, Intravenous
• Laser-Doppler Flowmetry
• Microcirculation (drug effects)
• Osteosarcoma (blood supply, drug therapy, veterinary)
• Time Factors