Differential expression of beta 2-integrins and cytokine production between gammadelta and alphabeta T cells in experimental autoimmune encephalomyelitis.

Abstract

The expression of beta 2-integrins on gammadelta T cells in naïve mice or those with experimental autoimmune encephalomyelitis (EAE) remains poorly characterized. We compared beta 2-integrin expression and cytokine production between gammadelta and alphabeta T cells over the acute course of EAE. We observed that unlike in alphabeta T cells, beta 2-integrin expression on gammadelta T cells increased significantly from baseline, peaked at Day 10, and remained unchanged in the draining lymph nodes or declined in the spleen and CNS by Day 15. In addition, IFN-gamma- and TNF-alpha-producing gammadelta T cells infiltrated the CNS rapidly and produced significantly more of these cytokines than alphabeta T cells throughout the course of EAE. These results suggest unique roles for beta 2-integrins in the trafficking of gammadelta versus alphabeta T cells during EAE and that gammadelta T cells infiltrate the CNS rapidly, producing cytokines, which modulate acute disease.

• Authors: Sherry S Smith, Scott R Barnum
• Journal: Journal of leukocyte biology (J Leukoc Biol) Vol. 83 Issue 1 Pg. 71-9 (Jan 2008) ISSN: 0741-5400 [Print] United States
• PMID: 17928460 (Publication Type: Journal Article, Research Support, N.I.H., Extramural, Research Support, Non-U.S. Gov't)

Chemical References

• CD18 Antigens
• Cytokines
• Receptors, Antigen, T-Cell, alpha-beta
• Receptors, Antigen, T-Cell, gamma-delta
• Tumor Necrosis Factor-alpha
• Interferon-gamma

Topics

• Animals
• CD18 Antigens (biosynthesis, immunology)
• Cytokines (biosynthesis, immunology)
• Disease Models, Animal
• Encephalomyelitis, Autoimmune, Experimental (immunology, pathology)
• Female
• Interferon-gamma (biosynthesis)
• Male
• Mice
• Mice, Inbred C57BL
• Receptors, Antigen, T-Cell, alpha-beta (immunology)
• Receptors, Antigen, T-Cell, gamma-delta (immunology)
• Spinal Cord (immunology)
• Spleen (immunology)
• T-Lymphocyte Subsets (immunology)
• Tumor Necrosis Factor-alpha (biosynthesis)