Potent inhibition of genital herpesvirus infection in goats by cidofovir.

Abstract

BACKGROUND:

Like human herpesvirus 2 (HHV-2) in humans, infection by caprine herpesvirus 1 in goats is associated with genital lesions, and this provides a unique model to study the efficacy and effects of anti-herpetic drugs.

METHODS:

The antiviral activity of cidofovir was assessed in goats infected experimentally, using various therapeutic protocols.

RESULTS:

Topic administration of cidofovir 1% cream prevented the onset of virus-induced genital lesions and drastically reduced virus shedding.

CONCLUSION:

Cidofovir appears to be a very efficient drug for the prevention of genital lesions caused by an alphaherpesvirus.

• Authors: Maria Tempesta, Michele Camero, Anna Lucia Bellacicco, Elvira Tarsitano, Giuseppe Crescenzo, Julien Thiry, Vito Martella, Nicola Decaro, Gabriella Elia, Johan Neyts, Etienne Thiry, Canio Buonavoglia
• Journal: Antiviral therapy (Antivir Ther) Vol. 12 Issue 6 Pg. 977-9 ( 2007) ISSN: 1359-6535 [Print] England
• PMID: 17926653 (Publication Type: Journal Article)

Chemical References

• Antiviral Agents
• Organophosphonates
• Cytosine
• Cidofovir

Topics

• Animals
• Antiviral Agents (therapeutic use)
• Cidofovir
• Cytosine (analogs & derivatives, therapeutic use)
• Goats
• Herpes Genitalis (drug therapy, virology)
• Herpesviridae Infections (drug therapy, virology)
• Organophosphonates (therapeutic use)
• Varicellovirus (drug effects)