Diterpenes from Cryptomeria japonica inhibit androgen receptor transcriptional activity in prostate cancer cells.

Abstract

We identified eight diterpenes from Cryptomeria japonica (Taxodiaceae), which inhibit the activity of the androgen receptor (AR) in human prostate cancer (PCa) 22Rv1-derived 103E cells. The compounds 6,12-dihydroxyabieta-5,8,11,13-tetraen-7-one ( 2), sugiol ( 3), ferruginol ( 4), and 5-epixanthoperol ( 7) have near 100 % AR inhibition efficacy at concentrations of 10, 5, 25, and 25 microM, respectively. Because these compounds have very similar structures, analysis of their differential activity may aid in the design of inhibitors for PCa treatment.

• Authors: Wei-Chun Tu, Sheng-Yang Wang, Shih-Chang Chien, Feng-Min Lin, Li-Ru Chen, Chih-Yang Chiu, Pei-Wen Hsiao
• Journal: Planta medica (Planta Med) Vol. 73 Issue 13 Pg. 1407-9 (Oct 2007) ISSN: 0032-0943 [Print] Germany
• PMID: 17924310 (Publication Type: Journal Article, Research Support, Non-U.S. Gov't)

Chemical References

• Antineoplastic Agents, Phytogenic
• Diterpenes
• Plant Extracts
• Receptors, Androgen

Topics

• Antineoplastic Agents, Phytogenic (administration & dosage, pharmacology, therapeutic use)
• Cell Line, Tumor (drug effects, metabolism)
• Cryptomeria
• Diterpenes (administration & dosage, pharmacology, therapeutic use)
• Humans
• Inhibitory Concentration 50
• Male
• Phytotherapy
• Plant Extracts (administration & dosage, pharmacology, therapeutic use)
• Prostatic Neoplasms (prevention & control)
• Receptors, Androgen (metabolism)