[The relationship between the exon 10 of the p47(phox) polymorphism and stroke and the effect of the polymorphism on plasma lipid].

Abstract

OBJECTIVE:

To investigate the relationship between C923T (Ala308Val) polymorphism in exon 10 of protein 47000 phagocyte oxidase(p47(phox)) gene and stroke and to evaluate the effect of C923T (Ala308Val) polymorphism on plasma lipid levels in Hunan Hans population.

METHODS:

Hunan Han population C923T (Ala308Val) polymorphism in p47phox gene was determined by PCR-single strand conformation polymorphism analysis and DNA sequencing in 100 healthy controls, 220 patients with stroke, and 10 stroke pedigrees. Plasma lipid levels were measured by routine methods.

RESULTS:

No statistically significant differences were found in frequencies of genotypes and alleles of C923T (Ala308Val) polymorphism between the controls and stroke patients (P > 0.05). The serum levels of triglyceride in cerebral infarction patients and controls with CT genotype were markedly higher than those with CC genotype (P < 0.05).

CONCLUSION:

There is no association between C923T (Ala308Val) polymorphism and stroke in Hunan Hans; C923T (Ala308Val) polymorphism is associated with plasma lipid metabolism in Hunan Han population with cerebral infarction.

• Authors: Xiao-song Huang, Qi-dong Yang, Tian-sheng Guo, Xian-yu Long, Jie Yang, Qing-ping Tang, Xiang-ming Sheng, Xiao-yan Zhu
• Journal: Zhonghua yi xue yi chuan xue za zhi = Zhonghua yixue yichuanxue zazhi = Chinese journal of medical genetics (Zhonghua Yi Xue Yi Chuan Xue Za Zhi) Vol. 24 Issue 5 Pg. 524-8 (Oct 2007) ISSN: 1003-9406 [Print] China
• PMID: 17922419 (Publication Type: Journal Article)

Chemical References

• Lipids
• NADPH Oxidases
• neutrophil cytosolic factor 1

Topics

• Adolescent
• Adult
• Aged
• Aged, 80 and over
• Base Sequence
• Case-Control Studies
• Ethnicity (genetics)
• Exons (genetics)
• Female
• Gene Frequency
• Genotype
• Humans
• Lipids (blood)
• Male
• Middle Aged
• NADPH Oxidases (genetics)
• Polymorphism, Single Nucleotide
• Polymorphism, Single-Stranded Conformational
• Stroke (blood, genetics)