Abstract |
We report on the relationships between serum cystatin C level, glomerular filtration rate (GFR) estimated from a cystatin C-based prediction equation (that of Filler and Lepage), GFR calculated by the Schwartz formula and technetium 99m-diethylene triamine penta- acetic acid ((99)Tc-DTPA)-determined GFR in 28 children with spina bifida. All children underwent measurement of height, weight, serum cystatin C level, and serum creatinine level at the time of their renal scan. The relationship between variables was assessed by Pearson correlation. Pearson correlation for the relationship between (99)Tc-DTPA GFR and GFR calculated by the cystatin C-based equation was significant and higher than that of the relationship between (99)Tc-DTPA GFR and GFR calculated by the Schwartz equation, which was not statistically significant. The correlation for Filler GFR was 0.42 (P = 0.03) and for Schwartz GFR was 0.21 (P = 0.28). Although we use renal scan determination of GFR as the best measure, and a creatinine-based formula as the most practical measure, perhaps a formula such as that published by Filler and Lepage, which is not dependent on anthropometric data, might be a more useful (and accurate) tool for establishing GFR in children with spina bifida.
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Authors | Catherine Morgan, Ambikaipakan Senthilselvan, Fiona Bamforth, Michael Hoskinson, Manjula Gowrishankar |
Journal | Pediatric nephrology (Berlin, Germany)
(Pediatr Nephrol)
Vol. 23
Issue 2
Pg. 329-32
(Feb 2008)
ISSN: 0931-041X [Print] Germany |
PMID | 17922294
(Publication Type: Journal Article, Research Support, Non-U.S. Gov't)
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Chemical References |
- CST3 protein, human
- Cerebrospinal Fluid Proteins
- Cystatin C
- Cystatins
- Radiopharmaceuticals
- Creatinine
- Technetium Tc 99m Pentetate
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Topics |
- Adolescent
- Cerebrospinal Fluid Proteins
(blood)
- Child
- Child, Preschool
- Creatinine
(blood)
- Cystatin C
- Cystatins
(blood)
- Female
- Glomerular Filtration Rate
- Humans
- Male
- Radioisotope Renography
- Radiopharmaceuticals
- Regression Analysis
- Spinal Dysraphism
(blood, diagnostic imaging, physiopathology)
- Technetium Tc 99m Pentetate
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