Early or up-front radiotherapy improved survival of localized extranodal NK/T-cell lymphoma, nasal-type in the upper aerodigestive tract.

Abstract

PURPOSE:

To investigate the role of early or up-front radiotherapy (RT), the optimal RT dose required to achieve appropriate treatment outcome and prognostic factors for patients with localized extranodal NK/T-cell lymphoma, nasal-type, in the upper aerodigestive tract.

METHODS AND MATERIALS:

Eighty-two patients were reviewed. Eight patients were treated with chemotherapy (CT) alone, 9 patients received RT alone, and 65 patients were given combined modality treatment of CT and RT (CMT). Of those 74 patients receiving RT, 31 patients were given up-front RT, whereas CT was the initial therapy for 43 patients and 41 of those 43 patients received early RT.

RESULTS:

Five-year overall survival (OS) and disease-free survival (DFS) were 52.3% and 39.2%, respectively. RT was the only independent prognostic factor for both OS and DFS at both the univariate and multivariate level. The 5-year OS and DFS were better in patients receiving >or=54 Gy of RT as compared with that of <54 Gy (5-year OS 75.5% vs. 46.1%, p = 0.019; 5-year DFS 60.3% vs. 33.4%, p = 0.004). Up-front RT presented better survival in Stage I patients when compared with that of initial CT followed by early RT (5-year OS 90.0% vs. 48.9%, p = 0.012; 5-year DFS 78.7% vs. 39.9%, p = 0.021).

CONCLUSION:

Early or up-front RT had an essential role in improved OS and DFS in patients with localized extranodal NK/T-cell lymphoma, nasal-type, in the upper aerodigestive tract. The recommended tumor dose was at least 54 Gy. Up-front RT may yield more benefits on survival in patients with Stage I disease.

• Authors: Mei-Juan Huang, Yu Jiang, Wei-Ping Liu, Zhi-Ping Li, Mei Li, Lin Zhou, Yong Xu, Chun-Hua Yu, Qiu Li, Feng Peng, Ji-Yan Liu, Feng Luo, You Lu
• Journal: International journal of radiation oncology, biology, physics (Int J Radiat Oncol Biol Phys) Vol. 70 Issue 1 Pg. 166-74 (Jan 01 2008) ISSN: 0360-3016 [Print] United States
• PMID: 17919841 (Publication Type: Journal Article)

Topics

• Analysis of Variance
• Antineoplastic Combined Chemotherapy Protocols (therapeutic use)
• Combined Modality Therapy (methods)
• Disease-Free Survival
• Female
• Head and Neck Neoplasms (drug therapy, mortality, radiotherapy)
• Humans
• Lymphoma, Extranodal NK-T-Cell (drug therapy, mortality, radiotherapy)
• Male
• Middle Aged
• Nose Neoplasms (drug therapy, mortality, radiotherapy)
• Radiotherapy Dosage
• Retrospective Studies
• Stomach Neoplasms (drug therapy, mortality, radiotherapy)
• Thoracic Neoplasms (drug therapy, mortality, radiotherapy)
• Treatment Outcome