Abstract | CONCLUSIONS: The determination of cyclin A expression might be helpful in the identification of laryngeal squamous cell cancer (LSCC) patients with increased risk of metastases. The results suggest that cyclin A may be a more informative marker for cell proliferation than Ki-67. Abnormalities of cyclin E and cyclin A may play an important role in LSCC development and progression; however, the expression of cyclin E does not seem to have prognostic significance. OBJECTIVE: The aim of the study was to elucidate a possible association between cyclin E and cyclin A expression and clinicopathologic factors and their potential role as prognostic markers for patients with laryngeal epithelial lesions. MATERIALS AND METHODS: Expression of cyclins E and A, and Ki-67 was examined immunohistochemically in a formalin-fixed, paraffin-embedded series of 46 LSCC; 23 epithelial dysplasias (ED); and 21 normal mucosae (NM). RESULTS: The mean labeling indices (LIs) for cyclin E in LSCC, ED, and NM were 10.6%, 4.9%, and 0%, and for cyclin A 27.2%, 17.5%, and 7%, respectively. In LSCC, a statistically significant correlation was found between enhanced cyclin A expression and a higher incidence of locoregional lymph node metastasis (p0.01). The enhanced expression of cyclin A was linked with cell proliferation in LSCC, ED, and NM. No association was observed between cyclin E and A and other clinicopathologic parameters or applied treatments. The prognostic significance of cyclin E, cyclin A, and Ki-67 in determining overall survival time showed no statistically significant differences.
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Authors | Marcin Fraczek, Zbigniew Wozniak, David Ramsey, Tomasz Zatonski, Tomasz Krecicki |
Journal | Acta oto-laryngologica
(Acta Otolaryngol)
Vol. 128
Issue 3
Pg. 329-34
(Mar 2008)
ISSN: 0001-6489 [Print] England |
PMID | 17917837
(Publication Type: Journal Article)
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Chemical References |
- Cyclin A
- Cyclin E
- Ki-67 Antigen
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Topics |
- Adult
- Aged
- Carcinoma, Squamous Cell
(genetics, pathology)
- Cell Division
(genetics)
- Cell Transformation, Neoplastic
(genetics, pathology)
- Cyclin A
(genetics)
- Cyclin E
(genetics)
- Female
- Gene Expression Regulation, Neoplastic
(genetics)
- Humans
- Immunoenzyme Techniques
- Ki-67 Antigen
(genetics)
- Laryngeal Neoplasms
(genetics, pathology)
- Lymphatic Metastasis
(genetics, pathology)
- Male
- Middle Aged
- Neoplasm Staging
- Prognosis
- Respiratory Mucosa
(pathology)
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