Clinicopathologic significance and prognostic role of cyclin E and cyclin A expression in laryngeal epithelial lesions.

The determination of cyclin A expression might be helpful in the identification of laryngeal squamous cell cancer (LSCC) patients with increased risk of metastases. The results suggest that cyclin A may be a more informative marker for cell proliferation than Ki-67. Abnormalities of cyclin E and cyclin A may play an important role in LSCC development and progression; however, the expression of cyclin E does not seem to have prognostic significance.
The aim of the study was to elucidate a possible association between cyclin E and cyclin A expression and clinicopathologic factors and their potential role as prognostic markers for patients with laryngeal epithelial lesions.
Expression of cyclins E and A, and Ki-67 was examined immunohistochemically in a formalin-fixed, paraffin-embedded series of 46 LSCC; 23 epithelial dysplasias (ED); and 21 normal mucosae (NM).
The mean labeling indices (LIs) for cyclin E in LSCC, ED, and NM were 10.6%, 4.9%, and 0%, and for cyclin A 27.2%, 17.5%, and 7%, respectively. In LSCC, a statistically significant correlation was found between enhanced cyclin A expression and a higher incidence of locoregional lymph node metastasis (p0.01). The enhanced expression of cyclin A was linked with cell proliferation in LSCC, ED, and NM. No association was observed between cyclin E and A and other clinicopathologic parameters or applied treatments. The prognostic significance of cyclin E, cyclin A, and Ki-67 in determining overall survival time showed no statistically significant differences.
AuthorsMarcin Fraczek, Zbigniew Wozniak, David Ramsey, Tomasz Zatonski, Tomasz Krecicki
JournalActa oto-laryngologica (Acta Otolaryngol) Vol. 128 Issue 3 Pg. 329-34 (Mar 2008) ISSN: 0001-6489 [Print] Norway
PMID17917837 (Publication Type: Journal Article)
Chemical References
  • Cyclin A
  • Cyclin E
  • Ki-67 Antigen
  • Adult
  • Aged
  • Carcinoma, Squamous Cell (genetics, pathology)
  • Cell Division (genetics)
  • Cell Transformation, Neoplastic (genetics, pathology)
  • Cyclin A (genetics)
  • Cyclin E (genetics)
  • Female
  • Gene Expression Regulation, Neoplastic (genetics)
  • Humans
  • Immunoenzyme Techniques
  • Ki-67 Antigen (genetics)
  • Laryngeal Neoplasms (genetics, pathology)
  • Lymphatic Metastasis (genetics, pathology)
  • Male
  • Middle Aged
  • Neoplasm Staging
  • Prognosis
  • Respiratory Mucosa (pathology)

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