Isolated cutaneous anaplastic large cell lymphoma progressing to severe systemic disease with myocardial involvement and central nervous system infiltration.

Abstract

Anaplastic large cell lymphoma (ALCL) is a rare tumor comprising around 10-15% of childhood lymphomas. We describe the case of a female who initially presented with localized skin disease associated with an insect bite. However, she subsequently relapsed with widespread systemic ALK-positive ALCL that included lymphoma deposits in the myocardium, a very rare manifestation. Her disease responded well to chemotherapy but she later developed a fatal relapse in the CNS. We also present data on an immune response to ALK, demonstrating a fluctuation in the levels of circulating antibodies to ALK corresponding to the different phases of her illness.

• Authors: Yi Fan Rannan-Eliya, Karen Pulford, Rob Johnson, Ian Peart, George Kokai, Colin Baillie, Kamel Ait-Tahar, Barry Pizer
• Journal: Pediatric blood & cancer (Pediatr Blood Cancer) Vol. 50 Issue 4 Pg. 879-81 (Apr 2008) ISSN: 1545-5017 [Electronic] United States
• PMID: 17914741 (Publication Type: Case Reports, Journal Article)
• Copyright: (c) 2008 Wiley-Liss, Inc.

Chemical References

• Oncogene Proteins, Fusion
• ALK protein, human
• Anaplastic Lymphoma Kinase
• Protein-Tyrosine Kinases
• Receptor Protein-Tyrosine Kinases

Topics

• Adolescent
• Anaplastic Lymphoma Kinase
• Antineoplastic Combined Chemotherapy Protocols (therapeutic use)
• Central Nervous System Neoplasms (drug therapy, genetics, pathology)
• Disease Progression
• Echocardiography, Transesophageal
• Fatal Outcome
• Female
• Heart Neoplasms (drug therapy, genetics, pathology)
• Humans
• Lymphoma, Large-Cell, Anaplastic (genetics, pathology, therapy)
• Myocardium
• Oncogene Proteins, Fusion (biosynthesis, genetics, immunology)
• Protein-Tyrosine Kinases (biosynthesis, genetics, immunology)
• Receptor Protein-Tyrosine Kinases
• Skin Neoplasms (genetics, pathology, surgery)