[Neurological involvement in Wegener's granulomatosis: report of one case].

Abstract

Wegener's granulomatosis is a systemic necrotizing vasculitis that affects medium size and small vessels. Neurological involvement occurs in 22% to 54% of patients, mainly in the form of mononeuritis multiplex. Central nervous system involvement is reported in only 2% to 8% of the cases. We report a 42-year-old male who presented with headache, diplopia, third and sixth cranial nerve palsies and left eye amaurosis associated to mass located in the Meckel cavum and diffuse meningeal involvement. A biopsy of the mass disclosed a chronic granulomatous necrotizing inflammation with Langhans giant cells. A chest CAT scan showed three cavitated lung nodules and ANCA antibodies were positive in a titer of 1:80. Treatment with steroid and cyclophosphamide was started and cranial nerve palsies resolved and the number and size of lung nodules decreased. The patient was lost from follow up.

• Authors: Raimundo López-Rodríguez, Jorge García-González, Joaquín Campos-Franco, Nieves Mallo-González, María Rosario Alende-Sixto
• Journal: Revista medica de Chile (Rev Med Chil) Vol. 135 Issue 7 Pg. 913-6 (Jul 2007) ISSN: 0034-9887 [Print] Chile
• Vernacular Title: Manifestaciones neurológicas de la granulomatosis de Wegener: Caso clínico.
• PMID: 17914549 (Publication Type: Case Reports, English Abstract, Journal Article)

Topics

• Adult
• Cranial Nerve Diseases (etiology)
• Granulomatosis with Polyangiitis (complications)
• Humans
• Male
• Meningitis, Aseptic (etiology)