Abstract | RATIONALE: OBJECTIVES: The present study examined the effects of galantamine and donepezil on PPI deficits induced by an environmental factor and drugs. MATERIALS AND METHODS: In the isolation-rearing model, 3-week-old male ddY mice were housed either in groups of five or six per cage or isolated in cages of the same size for more than 6 weeks. In the drug-induced model, apomorphine 1 mg/kg and MK-801 0.2 mg/kg were administered to 9- to 10-week-old male ddY mice. RESULTS: CONCLUSIONS: These observations suggest that galantamine and donepezil have different effects on the environmentally induced PPI deficits and that these observations may be relevant to the different effects of these drugs observed clinically in schizophrenia.
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Authors | Ken Koda, Yukio Ago, Toshiyuki Kawasaki, Hitoshi Hashimoto, Akemichi Baba, Toshio Matsuda |
Journal | Psychopharmacology
(Psychopharmacology (Berl))
Vol. 196
Issue 2
Pg. 293-301
(Feb 2008)
ISSN: 0033-3158 [Print] Germany |
PMID | 17912499
(Publication Type: Journal Article, Research Support, Non-U.S. Gov't)
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Chemical References |
- Cholinesterase Inhibitors
- Chrna7 protein, mouse
- Indans
- Nicotinic Antagonists
- Piperidines
- Receptors, Nicotinic
- alpha7 Nicotinic Acetylcholine Receptor
- Galantamine
- methyllycaconitine
- Mecamylamine
- Dizocilpine Maleate
- Donepezil
- Risperidone
- Apomorphine
- Aconitine
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Topics |
- Aconitine
(analogs & derivatives, pharmacology)
- Acoustic Stimulation
- Analysis of Variance
- Animals
- Animals, Outbred Strains
- Apomorphine
(pharmacology)
- Behavior, Animal
(drug effects, physiology)
- Cholinesterase Inhibitors
(pharmacology)
- Dizocilpine Maleate
(pharmacology)
- Donepezil
- Dose-Response Relationship, Drug
- Galantamine
(pharmacology)
- Indans
(pharmacology)
- Male
- Mecamylamine
(pharmacology)
- Mice
- Neural Inhibition
(drug effects, physiology)
- Nicotinic Antagonists
(pharmacology)
- Piperidines
(pharmacology)
- Receptors, Nicotinic
(physiology)
- Reflex, Startle
(drug effects)
- Risperidone
(pharmacology)
- Social Isolation
(psychology)
- alpha7 Nicotinic Acetylcholine Receptor
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