HOMEPRODUCTSCOMPANYCONTACTFAQResearchDictionaryPharmaSign Up FREE or Login

The alpha1beta1 integrin and TNF receptor II protect airway CD8+ effector T cells from apoptosis during influenza infection.

Abstract
Primary viral infections of the lung induce potent effector CD8 T cell responses. To function in the influenza-infected airways, CD8 T cells must be able to resist cell death. The majority of the CD8 T cells in the airways and lung parenchyma expressed CD49a, the alpha-chain of the type IV collagen receptor VLA-1, and these cells were highly activated, producing both IFN-gamma and TNF-alpha. In the airways, where type IV collagen is abundant, but not the spleen, the CD49a(+) CD8 cells had reduced proportions of annexin V and caspase 8, and >80% expressed the TNF-alpha receptor II, while Fas, TNFR-I, and CD27 expression were similar to CD49a(-) cells. Furthermore, the CD49a(+), but not CD49a(-), CD8 T cells from the airways were resistant to active induction of apoptosis in the presence of type IV collagen and TNF-alpha in vitro. We propose that TNFR-II and the VLA-1 synergize to protect effector CD8 T cells in the infected airways from apoptosis during the acute infection.
AuthorsMartin V Richter, David J Topham
JournalJournal of immunology (Baltimore, Md. : 1950) (J Immunol) Vol. 179 Issue 8 Pg. 5054-63 (Oct 15 2007) ISSN: 0022-1767 [Print] United States
PMID17911590 (Publication Type: Journal Article, Research Support, N.I.H., Extramural)
Chemical References
  • Integrin alpha1
  • Integrin alpha1beta1
  • Receptors, Tumor Necrosis Factor, Type II
Topics
  • Animals
  • Apoptosis (immunology)
  • CD8-Positive T-Lymphocytes (immunology, metabolism, pathology)
  • Cell Separation
  • Female
  • Immunophenotyping
  • Influenza A Virus, H3N2 Subtype (immunology)
  • Integrin alpha1 (biosynthesis, metabolism)
  • Integrin alpha1beta1 (physiology)
  • Mice
  • Mice, Inbred C57BL
  • Orthomyxoviridae Infections (immunology, metabolism, pathology)
  • Receptors, Tumor Necrosis Factor, Type II (physiology)
  • Respiratory Mucosa (immunology, metabolism, pathology)
  • T-Lymphocyte Subsets (immunology, metabolism, pathology)

Join CureHunter, for free Research Interface BASIC access!

Take advantage of free CureHunter research engine access to explore the best drug and treatment options for any disease. Find out why thousands of doctors, pharma researchers and patient activists around the world use CureHunter every day.
Realize the full power of the drug-disease research graph!


Choose Username:
Email:
Password:
Verify Password:
Enter Code Shown: