Abstract | PURPOSE: EXPERIMENTAL DESIGN: Biopsies of resected colorectal hepatic metastases and nonneoplastic adjacent liver tissue were screened for chemokines using protein arrays and results were confirmed by ELISA and immunohistochemistry. RESULTS: CONCLUSIONS: Taken together, these observations confirm eotaxin-2 as a chemokine strongly associated with primary and metastatic tumors of colorectal origin. Furthermore, the importance of this result may be a useful tool in the development of targeted therapeutic approaches to colorectal tumors.
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Authors | Eleanor J Cheadle, Kallingal Riyad, Daren Subar, Dominic G Rothwell, Garry Ashton, Hayley Batha, David J Sherlock, Robert E Hawkins, David E Gilham |
Journal | Clinical cancer research : an official journal of the American Association for Cancer Research
(Clin Cancer Res)
Vol. 13
Issue 19
Pg. 5719-28
(Oct 01 2007)
ISSN: 1078-0432 [Print] United States |
PMID | 17908961
(Publication Type: Journal Article, Research Support, Non-U.S. Gov't)
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Chemical References |
- Antineoplastic Agents
- Chemokine CCL2
- Chemokine CCL24
- Chemokines
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Topics |
- Antineoplastic Agents
(therapeutic use)
- Biopsy
- Cell Line, Tumor
- Cell Movement
- Chemokine CCL2
(metabolism)
- Chemokine CCL24
(physiology)
- Chemokines
(metabolism)
- Colorectal Neoplasms
(immunology, metabolism, therapy)
- Gene Expression Regulation, Neoplastic
- Humans
- Immune System
- Immunotherapy
(methods)
- Liver Neoplasms
(secondary)
- Neoplasm Metastasis
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