[The mechanisms of neutrophilic oxygen damage in ischemic and reperfusion lesions. Pharmacological manipulations].

Abstract

This work studies the ischemic/reperfusion injury (I/R) in relationship to the production of free radicals from activated neutrophils. It is well known, that biochemical and physiopathological alterations participate in the tissue lesion produced by the interaction oxygen/leukocyte. Pharmacological manipulations, oriented to eliminate the harmful effect of the free radicals, remain as the most significant event in the management of the I/R injury. Compounds such as allopurinol, adenosine, naloxone, corticosteroids, methylurea, and others, have demonstrated a protective effect during the I/R injury. Although, the mechanism of action of these compounds is unknown, it is possible that the free radical scavenging effect, could be the most important protective mechanism. The better understanding of the I/R injury would allow for a better protection of the damaged organ.

• Authors: L H Toledo-Pereyra
• Journal: Gaceta medica de Mexico (Gac Med Mex) 1991 Jul-Aug Vol. 127 Issue 4 Pg. 349-55; discussion 355-6 ISSN: 0016-3813 [Print] Mexico
• Vernacular Title: Mecanismos de daño neutrófilo-oxígeno en la lesión de isquemia y reperfusión. Manipulaciones farmacológicas.
• PMID: 1790844 (Publication Type: English Abstract, Journal Article, Review)

Chemical References

• Free Radical Scavengers
• Free Radicals

Topics

• Animals
• Free Radical Scavengers
• Free Radicals
• Neutrophils (drug effects, metabolism)
• Oxygen Consumption (drug effects)
• Reperfusion Injury (drug therapy, metabolism)