HOMEPRODUCTSSERVICESCOMPANYCONTACTFAQResearchDictionaryPharmaMobileSign Up FREE or Login

Prevalence and clinical associations of anticardiolipin antibodies in systemic lupus erythematosus: a prospective study.

Abstract
The main objectives of the present study were to determine the prevalence of IgG and IgM anticardiolipin antibody (aCL) isotypes in systemic lupus erythematosus (SLE) in order to analyze their possible association with the clinical manifestations of the disease. Clinical features of 64 consecutive and unselected SLE patients were prospectively studied. Sera from the same patients taken during each clinical manifestation were tested for the presence of aCL. The prevalence of aCL was 43.75% for the IgG isotype and 9.4% for the IgM isotype. A strong linkage between the presence of these antibodies and the occurrence of both thrombosis and abortions was found: a weaker association with neurological events and thrombocytopenia was also demonstrated. The titre of aCL appeared to be linked with the probability of having the clinical manifestations associated with these autoantibodies. Our results suggest that thrombosis and abortion, and possibly thrombocytopenia and central nervous system involvement, may be associated with the presence of aCL at the time when these clinical events develop in SLE patients.
AuthorsG D Sebastiani, G Passiu, M Galeazzi, F Porzio, U Carcassi
JournalClinical rheumatology (Clin Rheumatol) Vol. 10 Issue 3 Pg. 289-93 (Sep 1991) ISSN: 0770-3198 [Print] BELGIUM
PMID1790638 (Publication Type: Journal Article)
Chemical References
  • Antibodies
  • Cardiolipins
  • Immunoglobulin G
  • Immunoglobulin M
Topics
  • Adult
  • Antibodies (analysis)
  • Antiphospholipid Syndrome (complications)
  • Cardiolipins (immunology)
  • Enzyme-Linked Immunosorbent Assay
  • Female
  • Humans
  • Immunoglobulin G (analysis)
  • Immunoglobulin M (analysis)
  • Lupus Erythematosus, Systemic (complications, epidemiology, immunology)
  • Male
  • Prevalence
  • Prospective Studies

Join CureHunter, for free Research Interface BASIC access!

Take advantage of free CureHunter research engine access to explore the best drug and treatment options for any disease. Find out why thousands of doctors, pharma researchers and patient activists around the world use CureHunter every day.
Realize the full power of the drug-disease research network!


Choose Username:
Email:
Password:
Verify Password: