Abstract | BACKGROUND: RESULTS: CONCLUSION: Uptake of ciclesonide into A549 cells was more efficient than that of the less lipophilic fluticasone propionate. Intracellular concentrations of the pharmacologically active metabolite des-CIC were maintained for up to 24 h. The local anti-inflammatory activity of ciclesonide in the lung may be prolonged by the slow release of active drug from the depot of fatty acid esters.
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Authors | Takashi Nonaka, Rüdiger Nave, Nigel McCracken, Atsuko Kawashimo, Yasuhiro Katsuura |
Journal | BMC pharmacology
(BMC Pharmacol)
Vol. 7
Pg. 12
(Sep 27 2007)
ISSN: 1471-2210 [Electronic] England |
PMID | 17900334
(Publication Type: Comparative Study, Journal Article, Research Support, Non-U.S. Gov't)
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Chemical References |
- Pregnenediones
- ciclesonide
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Topics |
- Cell Line
- Epithelial Cells
(cytology, metabolism)
- Humans
- Pregnenediones
(chemistry, metabolism)
- Pulmonary Alveoli
(cytology, metabolism)
- Respiratory Mucosa
(cytology, metabolism)
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