Neutrophil-specific antigen HNA-2a, NB1 glycoprotein, and CD177.

Abstract

PURPOSE OF REVIEW:

Several advances have been made in characterization of the molecule that carries human neutrophil antigen (HNA)-2a, NB1 glycoprotein, the gene that encodes NB1 glycoprotein, CD177, and the role of antibodies to HNA-2a in transfusion reactions.

RECENT FINDINGS:

NB1 glycoprotein binds to the endothelial cell adhesion molecule, platelet endothelial cell adhesion molecule-1 (PECAM-1), and participates in neutrophil transmigration. The overexpression of neutrophil CD177 mRNA has become a useful, but nonspecific biomarker of myeloproliferative diseases, especially polycythemia vera. CD177 mRNA overexpression is also a biomarker of a subset of patients with essential thrombocythemia who are at increased risk of thromboembolic complications. In patients with myeloproliferative disorders CD177 mRNA overexpression is secondary to a gain-of-function mutation in JAK2, JAK2 V617F. NB1 glycoprotein is co-localized on neutrophil plasma membranes with proteinase 3 and a complex of NB1 glycoprotein and proteinase 3 may initiate the activation of neutrophils by antineutrophil cytoplasmic antibodies in patients with Wegener's granulomatosis. The inadvertent transfusion of antibodies to HNA-2a with blood components frequently causes pulmonary transfusion reactions.

SUMMARY:

The expression of CD177 is an important biomarker of myeloproliferative diseases, NB1 glycoprotein is a ligand for PECAM-1 and it may have a role in Wegener's granulomatosis, and antibodies to HNA-2a frequently cause pulmonary transfusion reactions.

• Authors: David F Stroncek
• Journal: Current opinion in hematology (Curr Opin Hematol) Vol. 14 Issue 6 Pg. 688-93 (Nov 2007) ISSN: 1065-6251 [Print] United States
• PMID: 17898576 (Publication Type: Journal Article, Review)

Chemical References

• Antigens, Surface
• Biomarkers
• CD177 protein, human
• GPI-Linked Proteins
• Isoantigens
• Membrane Glycoproteins
• Platelet Endothelial Cell Adhesion Molecule-1
• Receptors, Cell Surface

Topics

• Antigens, Surface (immunology)
• Biomarkers (blood)
• Cell Membrane (immunology)
• GPI-Linked Proteins
• Granulomatosis with Polyangiitis (immunology)
• Humans
• Isoantigens (immunology)
• Membrane Glycoproteins (immunology)
• Neutrophils (immunology)
• Platelet Endothelial Cell Adhesion Molecule-1 (immunology)
• Polycythemia Vera (immunology)
• Receptors, Cell Surface (immunology)
• Thrombocythemia, Essential (immunology)
• Transfusion Reaction