Plasma renin and risk of cardiovascular disease and mortality: the Framingham Heart Study.

Abstract

AIMS:

Previous studies relating plasma renin to cardiovascular disease (CVD) and mortality yielded conflicting results. We related plasma renin to incidence of CVD and mortality in 3408 individuals (mean age 59; 53% women) and in a hypertensive subset (n = 1413).

METHODS AND RESULTS:

On follow-up (mean 7.1 years), 176 participants (122 hypertensives) developed CVD and 215 individuals (127 hypertensives) died. Overall, log-renin was associated with mortality [multivariable-adjusted hazards ratio (HR) per SD increment: in whole sample, 1.14, 95% confidence interval (CI) 1.00-1.30, P = 0.046; hypertensives, 1.16, 95% CI 1.00-1.35, P = 0.046], but relations varied over time (P < 0.02). Log-renin was associated with mortality at 2.5 years of follow-up (HR per SD increment: whole sample at 2.5 years, 1.23, 95% CI 1.04-1.45; hypertensives at 2 years, 1.28, 95% CI 1.06-1.54), but not during longer follow-up (HR per SD increment at 5 years: whole sample, 1.02, 95% CI 0.80-1.29; hypertensives, 0.98, 95% CI 0.74-1.30). The time-dependent relation of renin and mortality risk was maintained upon excluding participants with prevalent CVD. Renin was not associated with CVD incidence (HR per SD increment log-renin: whole sample, 0.99, 95% CI 0.85-1.14; hypertensives, 0.96, 95% CI 0.82-1.12).

CONCLUSION:

Higher plasma renin was associated with greater short-term mortality but not with CVD incidence in the community.

• Authors: Nisha I Parikh, Philimon Gona, Martin G Larson, Thomas J Wang, Christopher Newton-Cheh, Daniel Levy, Emelia J Benjamin, William B Kannel, Ramachandran S Vasan
• Journal: European heart journal (Eur Heart J) Vol. 28 Issue 21 Pg. 2644-52 (Nov 2007) ISSN: 0195-668X [Print] England
• PMID: 17895253 (Publication Type: Journal Article, Research Support, N.I.H., Extramural)

Chemical References

• Biomarkers
• Renin

Topics

• Biomarkers (blood)
• Cardiovascular Diseases (blood, mortality)
• Epidemiologic Methods
• Female
• Humans
• Hypertension (blood, mortality)
• Male
• Middle Aged
• Renin (blood)