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Clinical trial: an efficacy evaluation of reduced bisacodyl given as part of a polyethylene glycol electrolyte solution preparation prior to colonoscopy.

AbstractBACKGROUND:
In an attempt to further improve patient preparation experience with reduced volume gut lavage solutions using 2-L sulphate-free electrolyte lavage solution plus 20-mg bisacodyl (HalfLytely with Bisacodyl Tablets Bowel Prep Kit, Braintree Laboratories, Inc., Braintree, MA, USA), a low bisacodyl dose preparation was developed using 10 mg bisacodyl.
AIM:
To compare preparation methods using the 10- or 20-mg bisacodyl with 2-L sulphate-free electrolyte lavage method.
METHODS:
At 10 US centres, 455 patients undergoing colonoscopy for routine clinical indications were equally randomized to receive 10- or 20-mg bisacodyl with 2-L sulphate-free electrolyte lavage method. Colonoscopists rated the efficacy of colon cleansing, blinded to the preparation assignment.
RESULTS:
Physician assessment of colon cleansing showed no difference between those randomized to receive the 10- or 20-mg bisacodyl preparations (P = 0.52). The 10-mg preparation had lower symptom scores for cramping (P < 0.001) and overall discomfort (P = 0.001). Other reported adverse experiences were few, mild and not different between groups.
CONCLUSION:
Two-litre sulphate-free electrolyte lavage method solution with 10-mg bisacodyl is as effective as the 20-mg bisacodyl preparation for cleansing the colon prior to colonoscopy. The 10-mg bisacodyl regimen has an improved safety profile, with significantly reduced cramping, nausea and overall discomfort.
AuthorsJ A DiPalma, J McGowan, M Vb Cleveland
JournalAlimentary pharmacology & therapeutics (Aliment Pharmacol Ther) Vol. 26 Issue 8 Pg. 1113-9 (Oct 15 2007) ISSN: 0269-2813 [Print] England
PMID17894653 (Publication Type: Journal Article, Multicenter Study, Randomized Controlled Trial, Research Support, Non-U.S. Gov't)
Chemical References
  • Cathartics
  • Bisacodyl
  • Polyethylene Glycols
Topics
  • Adult
  • Aged
  • Aged, 80 and over
  • Bisacodyl (administration & dosage, adverse effects)
  • Cathartics (administration & dosage, adverse effects)
  • Colonoscopy (methods)
  • Dose-Response Relationship, Drug
  • Female
  • Gastric Lavage (methods)
  • Humans
  • Male
  • Middle Aged
  • Patient Compliance
  • Polyethylene Glycols (administration & dosage, adverse effects)
  • Preoperative Care (methods)
  • Treatment Outcome
  • United States

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