Abstract | PURPOSE: The aim of this study is to determine whether 5-fluorouracil ( 5FU) used in the infusion fluid during vitrectomy is systemically absorbed. PATIENTS AND METHODS: RESULTS: In both patients, FBAL was found in the urine samples collected up to 48 hours after the surgery, with the highest concentration and total amount in the first 6 hours after the first urine production after surgery. Moreover, the concentration and total amount of FBAL was higher in the patient who received silicone oil tamponade (versus 12.5% SF6), with the longest surgery time (40 min versus 20 min) and the highest amount of infusion fluid used (350 ml versus 250 ml). CONCLUSIONS:
5FU, used to prevent the formation of proliferative vitreoretinopathy (PVR), is systemically absorbed when used in infusion fluid during vitrectomy. As such, patient selection is needed to avoid adverse effects on procreativity. Further studies will be needed to determine which clinical setting will influence most the absorption.
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Authors | O Creten, W Spileers, P Stalmans |
Journal | Bulletin de la Societe belge d'ophtalmologie
(Bull Soc Belge Ophtalmol)
Issue 303
Pg. 37-41
( 2007)
ISSN: 0081-0746 [Print] Belgium |
PMID | 17894285
(Publication Type: Journal Article)
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Chemical References |
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Topics |
- Absorption
- Fluorouracil
(pharmacokinetics, therapeutic use, urine)
- Humans
- Vitrectomy
(adverse effects, methods)
- Vitreoretinopathy, Proliferative
(etiology, prevention & control)
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