Intravitreal bevacizumab for the management of choroidal neovascularization in pseudoxanthoma elasticum.

Abstract

PURPOSE:

To determine the results of intravitreal bevacizumab injections for the management of choroidal neovascularization (CNV) in patients with pseudoxanthoma elasticum (PXE)-associated angioid streaks.

METHODS:

A consecutive series of patients with PXE and CNV were managed with intravitreal bevacizumab injection (1.25 mg per 0.05 cc). The main outcome measures were visual acuity and greatest lesion height as measured by optical coherence tomography (OCT).

RESULTS:

Nine eyes of nine consecutive patients received intravitreal bevacizumab (1.25 mg/0.05 mL) injections. The mean follow-up time was 6 months, during which eyes received an average of 1.8 injections. The baseline visual acuity was a mean of 20/368 and improved to 20/289 at the last visit (P = 0.056). Visual acuity either improved or stabilized in all 9 eyes (100%). Serial OCT measurements in 8 eyes showed a mean of 353 microm at baseline, which decreased to 201 mum at the last visit (P = 0.012). No complications were noted.

CONCLUSIONS:

These short-term results support the use of intravitreal bevacizumab for the management of CNV in patients with PXE. Continued experience with intravitreal bevacizumab in this population will help establish its longer-term efficacy and better define the potential need for serial injections to maintain these results.

• Authors: Pawan Bhatnagar, K Bailey Freund, Richard F Spaide, James M Klancnik Jr, Michael J Cooney, Ivan Ho, Howard F Fine, Lawrence A Yannuzzi
• Journal: Retina (Philadelphia, Pa.) (Retina) Vol. 27 Issue 7 Pg. 897-902 (Sep 2007) ISSN: 0275-004X [Print] United States
• PMID: 17891014 (Publication Type: Journal Article, Research Support, Non-U.S. Gov't)

Chemical References

• Angiogenesis Inhibitors
• Antibodies, Monoclonal
• Antibodies, Monoclonal, Humanized
• VEGFA protein, human
• Vascular Endothelial Growth Factor A
• Bevacizumab

Topics

• Adult
• Aged
• Angiogenesis Inhibitors (therapeutic use)
• Angioid Streaks (complications, diagnosis)
• Antibodies, Monoclonal (therapeutic use)
• Antibodies, Monoclonal, Humanized
• Bevacizumab
• Choroidal Neovascularization (diagnosis, drug therapy, etiology)
• Female
• Fluorescein Angiography
• Follow-Up Studies
• Humans
• Injections
• Male
• Middle Aged
• Pseudoxanthoma Elasticum (complications, diagnosis)
• Tomography, Optical Coherence
• Treatment Outcome
• Vascular Endothelial Growth Factor A (antagonists & inhibitors)
• Visual Acuity
• Vitreous Body