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A role of RGS proteins in drug addiction.

Abstract
The diverse family of Regulators of G protein signaling (RGS) proteins are widely distributed proteins with multiple functions, including GAP activity for heterotrimeric G protein alpha subunits. Three members of the RGS family, RGS9-2, RGS4 and RGSz, have been shown to play an essential modulatory role in psychostimulant and opiate drug actions. Interestingly, these proteins show distinct structure, distribution pattern and cellular localization. In addition, each of these proteins is differentially regulated by drugs of abuse in particular brain networks and appears to modulate distinct signal transduction events. The striatal enriched RGS9 plays a prominent role in opiate and psychostimulant drug reward; RGS4 appears to modulate opiate dependence via actions in the locus coeruleus, whereas RGSz modulates analgesia via activation of the PKC pathway.
AuthorsShelley B Hooks, Kirill Martemyanov, Venetia Zachariou
JournalBiochemical pharmacology (Biochem Pharmacol) Vol. 75 Issue 1 Pg. 76-84 (Jan 01 2008) ISSN: 0006-2952 [Print] England
PMID17880927 (Publication Type: Journal Article, Review)
Chemical References
  • RGS Proteins
  • Receptors, G-Protein-Coupled
  • Receptors, Opioid, mu
  • regulator of g-protein signaling 9
  • RGS4 protein
  • Dopamine
Topics
  • Animals
  • Brain (metabolism)
  • Dopamine (physiology)
  • Humans
  • RGS Proteins (chemistry, physiology)
  • Receptors, G-Protein-Coupled (physiology)
  • Receptors, Opioid, mu (physiology)
  • Substance-Related Disorders (etiology)

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