Abstract | BACKGROUND: CASE REPORT: A 64-year-old woman with fatigue was found to be profoundly anemic with laboratory findings consistent with AIHA. She was admitted for the workup and management of her disease after she failed to respond to a course of oral steroids. Laboratory evaluation demonstrated a positive DL test suggesting PCH. She was given a course of rituximab that resulted in normalization of her hemoglobin concentration. She presented 9 months later with recurrent hemolysis. She was given another course of rituximab that again resulted in termination of hemolysis. The patient remained in remission since her last dose of rituximab 19 months previously. CONCLUSION: To our knowledge, this is the first report of an adult case of refractory PCH successfully treated with rituximab.
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Authors | Ahrin Koppel, Stephen Lim, Melanie Osby, George Garratty, Dennis Goldfinger |
Journal | Transfusion
(Transfusion)
Vol. 47
Issue 10
Pg. 1902-4
(Oct 2007)
ISSN: 0041-1132 [Print] United States |
PMID | 17880618
(Publication Type: Case Reports, Journal Article)
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Chemical References |
- Antibodies, Monoclonal
- Antibodies, Monoclonal, Murine-Derived
- Immunologic Factors
- Rituximab
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Topics |
- Anemia
(etiology)
- Antibodies, Monoclonal
(therapeutic use)
- Antibodies, Monoclonal, Murine-Derived
- Female
- Hemoglobinuria, Paroxysmal
(drug therapy)
- Humans
- Immunologic Factors
(therapeutic use)
- Middle Aged
- Rituximab
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