Significance of immunohistochemical expression of p27 and involucrin as the marker of cellular differentiation of squamous cell carcinoma of the esophagus.

Abstract

PURPOSE:

p27kip1 belongs to the KIP/CIP family of cyclin-dependent kinase inhibitors and is considered to be a tumor suppressor. Involucrin has been known as a marker of differentiation of squamous cell carcinoma (SCC). The aim of this study was to evaluate the clinicopathologic significance of the expression of p27 and involucrin in esophageal SCC.

METHODS:

Immunohistochemical expression of p27 and involucrin was examined in 70 specimens of esophageal SCC. The correlation of the expression of these proteins and clinicopathologic features was evaluated.

RESULTS:

Cellular differentiation in esophageal SCC was significantly correlated with the expression of p27 and involucrin (p = 0.010 and p = 0.002, respectively). Among well, moderately and poorly differentiated SCCs, 45.8 +/- 21.6, 20.0 +/- 15.0 and 10.6 +/- 9.1% of carcinoma cells expressed involucrin, respectively (p < 0.0001 for well vs. poorly, p < 0.0001 for well vs. moderately, and p = 0.042 for moderately vs. poorly). There existed a more powerful statistical difference regarding the histological grade between SCCs with the expression of both p27 and involucrin and tumors with other expression patterns (p = 0.0001).

CONCLUSIONS:

Expression of both p27 and involucrin can be a powerful biological marker of cellular differentiation of esophageal SCC.

• Authors: Tadahiro Nozoe, Tsunehiro Oyama, Mistuhiro Takenoyama, Takeshi Hanagiri, Kenji Sugio, Kosei Yasumoto
• Journal: Oncology (Oncology) Vol. 71 Issue 5-6 Pg. 402-10 ( 2006) ISSN: 1423-0232 [Electronic] Switzerland
• PMID: 17878746 (Publication Type: Journal Article)
• Copyright: Copyright 2006 S. Karger AG, Basel.

Chemical References

• Antigens, Differentiation
• Biomarkers, Tumor
• Protein Precursors
• Cyclin-Dependent Kinase Inhibitor p27
• involucrin

Topics

• Adult
• Aged
• Aged, 80 and over
• Antigens, Differentiation (biosynthesis)
• Biomarkers, Tumor (biosynthesis)
• Carcinoma, Squamous Cell (classification, metabolism, pathology)
• Cell Differentiation
• Cyclin-Dependent Kinase Inhibitor p27 (biosynthesis)
• Disease Progression
• Esophageal Neoplasms (classification, metabolism, pathology)
• Female
• Humans
• Immunohistochemistry
• Male
• Middle Aged
• Protein Precursors (biosynthesis)
• Survival Rate