Adult methicillin-resistant Staphylococcus aureus bacteremia in Taiwan: clinical significance of non-multi-resistant antibiogram and Panton-Valentine leukocidin gene.

Abstract

It is poorly defined whether or not adult patients with methicillin-resistant Staphylococcus aureus (MRSA) bacteremia with a non-multi-resistant antibiogram phenotype and Panton-Valentine leukocidin (PVL) gene carriage have different clinical syndromes. Clinical characteristics of 95 adult patients of MRSA bacteremia, with isolates that were non-multi-resistant to non-beta-lactam, were compared with a contemporaneous multiresistant group. Independent risk factors other than community-associated MRSA bacteremia patients associated with recovery of non-multi-resistant MRSA isolates by multivariate analysis included deep-seated infection and catheter insertion site infection. Older age, intensive care unit-onset bacteremia, and postoperative infection were negative independent risk factors associated with non-multi-resistant MRSA isolates. Most of the 60 recoverable non-multi-resistant MRSA isolates belonged to multilocus sequence type 59, and all isolates belonged to staphylococcal chromosomal cassette mec (SCCmec) element type IV or type V. Most PVL-positive MRSA isolates belonged to SCCmec V. PVL-positive CA-MRSA isolates could cause more deep-seated infections in patients presented with non-multi-resistant MRSA bacteremia.

• Authors: Jiun-Ling Wang, Jann-Tay Wang, Shey-Ying Chen, Po-Ren Hsueh, Hsiang-Chi Kung, Yee-Chun Chen, Shan-Chwen Chang
• Journal: Diagnostic microbiology and infectious disease (Diagn Microbiol Infect Dis) Vol. 59 Issue 4 Pg. 365-71 (Dec 2007) ISSN: 0732-8893 [Print] United States
• PMID: 17878063 (Publication Type: Journal Article, Research Support, Non-U.S. Gov't)

Chemical References

• Anti-Bacterial Agents
• Bacterial Toxins
• Exotoxins
• Leukocidins
• Panton-Valentine leukocidin

Topics

• Adult
• Aged
• Anti-Bacterial Agents (pharmacology)
• Bacteremia (epidemiology, microbiology)
• Bacterial Toxins (genetics)
• Community-Acquired Infections (epidemiology, microbiology)
• Drug Resistance, Multiple, Bacterial
• Exotoxins (genetics)
• Female
• Humans
• Leukocidins (genetics)
• Male
• Methicillin Resistance
• Microbial Sensitivity Tests
• Middle Aged
• Risk Factors
• Staphylococcal Infections (epidemiology, microbiology)
• Staphylococcus aureus (drug effects, isolation & purification)
• Taiwan (epidemiology)