Abstract | BACKGROUND: The clinical significance of the trophic effects of long-term proton pump inhibitors (PPI)-related hypergastrinemia on colon polyps remains unknown. AIM: To study the frequency, growth, and histology of colon polyps in patients on chronic PPI therapy (cases), compared to those not receiving acid suppression (controls). METHODS: Medical records of 2868 consecutive patients who underwent two or more colonoscopies, performed 3 or more months apart were reviewed. Cases (116) that used PPIs between the two colonoscopies were then compared to controls (194). RESULTS: Demographics and risk factors for colon cancer were comparable between the two groups. At baseline the mean frequency and size of adenomatous polyps were similar in cases and controls (P > 0.05) and at follow-up, these were 0.89 and 1.18 (P > 0.05; 95% CI of -0.08 to 0.66) and 4.09 mm and 4.00 mm (P > 0.05; 95% CI -2.29 to 2.11), respectively with no significant change. However, control group had a higher mean frequency and size of hyperplastic polyps at baseline as well as at follow-up colonoscopy (P < 0.05). CONCLUSIONS: The long-term use of PPI does not influence the frequency, growth, or histology of adenomatous polyps, but is associated with a reduction in both baseline and interval development of hyperplastic polyps.
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Authors | M Singh, G Dhindsa, S Friedland, G Triadafilopoulos |
Journal | Alimentary pharmacology & therapeutics
(Aliment Pharmacol Ther)
Vol. 26
Issue 7
Pg. 1051-61
(Oct 01 2007)
ISSN: 0269-2813 [Print] England |
PMID | 17877512
(Publication Type: Comparative Study, Journal Article, Research Support, N.I.H., Extramural)
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Chemical References |
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Topics |
- Adenomatous Polyps
(drug therapy, metabolism)
- Colonic Polyps
(drug therapy, metabolism)
- Colonoscopy
- Female
- Humans
- Male
- Middle Aged
- Proton Pump Inhibitors
(metabolism, therapeutic use)
- Retrospective Studies
- Treatment Outcome
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