Effect of sesame oil on diuretics or Beta-blockers in the modulation of blood pressure, anthropometry, lipid profile, and redox status.

Abstract

The study was undertaken to investigate the effect of sesame oil in hypertensive patients who were on antihypertensive therapy either with diuretics (hydrochlorothiazide) or Beta-blockers (atenolol). Thirty-two male and 18 female patients aged 35 to 60 years old were supplied sesame oil (Idhayam gingelly oil) and instructed to use it as the only edible oil for 45 days. Blood pressure, anthropometry, lipid profile, lipid peroxidation, and enzymic and non-enzymic antioxidants were measured at baseline and after 45 days of sesame oil substitution. Substitution of sesame oil brought down systolic and diastolic blood pressure to normal. The same patients were asked to withdraw sesame oil consumption for another 45 days, and the measurements were repeated at the end of withdrawal period. Withdrawal of sesame oil substitution brought back the initial blood pressure values. A significant reduction was noted in body weight and body mass index (BMI) upon sesame oil substitution. No significant alterations were observed in lipid profile except triglycerides. Plasma levels of sodium reduced while potassium elevated upon the substitution of sesame oil. Lipid peroxidation (thiobarbituric acid reactive substances [TBARS]) decreased while the activities of superoxide dismutase (SOD), catalase (CAT), and the levels of vitamin C, vitamin E, Beta-carotene, and reduced glutathione (GSH) were increased. The results suggested that sesame oil as edible oil lowered blood pressure, decreased lipid peroxidation, and increased antioxidant status in hypertensive patients.

• Authors: D Sankar, M Ramakrishna Rao, G Sambandam, K V Pugalendi
• Journal: The Yale journal of biology and medicine (Yale J Biol Med) Vol. 79 Issue 1 Pg. 19-26 (Mar 2006) ISSN: 1551-4056 [Electronic] United States
• PMID: 17876372 (Publication Type: Controlled Clinical Trial, Journal Article)

Chemical References

• Adrenergic beta-Antagonists
• Antioxidants
• Diuretics
• Drug Combinations
• Sesame Oil

Topics

• Adrenergic beta-Antagonists (administration & dosage)
• Adult
• Antioxidants (metabolism)
• Blood Pressure (drug effects)
• Diuretics (administration & dosage)
• Drug Combinations
• Drug Interactions
• Female
• Humans
• Hypertension (drug therapy, physiopathology)
• Lipid Peroxidation (drug effects)
• Male
• Middle Aged
• Oxidation-Reduction (drug effects)
• Sesame Oil (administration & dosage)
• Treatment Outcome