Hypersplenism induced by splenic vein ligation.

Abstract

Warm autoimmune hemolytic anemia (AIHA) is a rare clinical entity. It is usually caused by an IgG autoantibody directed against the red blood cell membrane that causes extravascular hemolysis predominantly in the spleen. As a result, disease states or procedures that result in hypersplenism would be expected to increase red cell destruction in patients with an underlying warm AIHA. We present the case of a patient with a previously undiagnosed warm AIHA, who developed worsening hemolysis after undergoing splenic vein ligation during a pancreaticoduodenectomy to remove a neuroendocrine tumor.

• Authors: Brian Garibaldi, Karen E King, Julie M Jaffe, Alison R Moliterno
• Journal: American journal of hematology (Am J Hematol) Vol. 83 Issue 3 Pg. 242-4 (Mar 2008) ISSN: 0361-8609 [Print] United States
• PMID: 17874452 (Publication Type: Case Reports, Journal Article)
• Copyright: (c) 2007 Wiley-Liss, Inc.

Topics

• Anemia, Hemolytic, Autoimmune (blood, complications)
• Blood Transfusion
• Duodenum (surgery)
• Hemolysis
• Humans
• Hypersplenism (surgery)
• Male
• Middle Aged
• Pancreatectomy
• Splenic Vein (surgery)
• Treatment Outcome