[Nitric oxide is involved in the protective effects of short-term adaptaion to hypoxia in the course of stress-induced disorders in Krushinsky-Molodkina rats].

Abstract

A possible involvement of nitric oxide in the protective effect of short-term adaptation of Krushinsky-Molodkina rats to mild hypoxia simulating 5000 m above sea level was studied. Nitric oxide proved to have a considerable protective effect on stress-induced disorders in Krushinsky-Molodkina rats as demonstrated using NO-synthase inhibitors and NO monitoring by electron spin resonance under different experimental conditions.

• Authors: A L Krushinskiĭ, V P Reutov, V S Kuzenkov, E G Sorokina, V B Koshelev, O E Fadiukova, L M Baĭder, Z V Kuropteva, T T Zhumambaeva, L Kh Komissarova, T V Riasina, N S Kositsyn, V G Pinelis
• Journal: Izvestiia Akademii nauk. Seriia biologicheskaia (Izv Akad Nauk Ser Biol) 2007 May-Jun Issue 3 Pg. 329-35 ISSN: 1026-3470 [Print] Russia (Federation)
• PMID: 17853695 (Publication Type: Journal Article)

Chemical References

• Enzyme Inhibitors
• Nitric Oxide
• Nitric Oxide Synthase

Topics

• Adaptation, Physiological (drug effects, physiology)
• Animals
• Electron Spin Resonance Spectroscopy
• Enzyme Inhibitors (pharmacology)
• Hypoxia (metabolism, prevention & control)
• Male
• Nitric Oxide (metabolism)
• Nitric Oxide Synthase (antagonists & inhibitors, metabolism)
• Rats
• Stress, Physiological (metabolism, prevention & control)