Mass protection program of perinatal hepatitis B virus infection in Japan and impact of an optional booster vaccination on its efficacy.
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| Abstract |
We assessed the efficacy of a government-sponsored mass protection program in Osaka, Japan, for perinatal HBV infection in infants born to HBeAg positive HBV carrier mothers. We also evaluated the impact of optional follow-up procedures in such infants, including an evaluation of anti-HBs response and a booster dose of HBV vaccine for poor responders. The results demonstrated that this mass protection program protected 94.4% of the infants from perinatal HBV infection in the Osaka area. However, the proportion of infants with an unprotective level of anti-HBs was higher in the standard group than in the follow-up group both at 1.0 and 1.5 years of age, which was also the case for HBV events. Furthermore, the present study showed that a booster dose of vaccine in poor responders was very effective in promoting an anti-HBs response. In conclusion, we recommend that a follow-up blood test to confirm a response of anti-HBs to HBV vaccine should be performed at 4-8 weeks after the third injection of HBV vaccine in infants born to HBeAg positive HBV carrier mothers. We also recommend that a booster injection of HBV vaccine should be immediately given to poor responding infants who otherwise are at a considerable risk of developing HBV infection in late infancy.
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| Authors | H Tajiri, K Kozaiwa, T Harada, Y Ozaki, K Miki, K Shimizu, S Okada |
| Journal | Acta paediatrica Japonica : Overseas edition (Acta Paediatr Jpn) Vol. 33 Issue 3 Pg. 323-6 (Jun 1991) ISSN: 0374-5600 [Print] Australia |
| PMID | 1785327 (Publication Type: Journal Article, Research Support, Non-U.S. Gov't) |
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