[Diabetes insipidus revealing chronic myelomonocytic leukemia].

Abstract

INTRODUCTION:

Central diabetes insipidus is most frequently reported to occur after a trauma from surgery or accident. However, between 30 and 50% of cases are considered idiopathic. It's a rare complication of myelodysplastic syndrome.

CASE REPORT:

A 61-year-old patient presented central diabetes insipidus revealing, 17 months before, chronic myelomonocytic leukemia. Cytogenetics studies revealed monosomy 7. Acute myeloid leukemia appears 3 months after training rapid patient's death.

DISCUSSION:

Blood examination is necessary before to conclude idiopathic central diabetes insipidus. The discovery of chronic myelomonocytic leukemia implicates a rapid managing before its possible acute myeloid leukemia transformation. Indeed, prognosis of central diabetes insipidus and acute myeloid leukemia associated, in presence of monosomy 7, is very poor.

• Authors: B Graffin, P Bernard, C Landais, O Gisserot, M Aletti, G Leyral, J-F Paris, P Carli
• Journal: La Revue de medecine interne (Rev Med Interne) Vol. 28 Issue 10 Pg. 698-700 (Oct 2007) ISSN: 0248-8663 [Print] France
• Vernacular Title: Diabète insipide central inaugural d'une leucémie myélomonocytaire chronique.
• PMID: 17850929 (Publication Type: Case Reports, English Abstract, Journal Article)

Topics

• Chromosomes, Human, Pair 7 (genetics)
• Diabetes Insipidus (diagnosis)
• Diagnosis, Differential
• Fatal Outcome
• Humans
• Leukemia, Myeloid, Acute (diagnosis)
• Leukemia, Myelomonocytic, Chronic (diagnosis)
• Male
• Middle Aged
• Monosomy (diagnosis, genetics)