Atypical antipsychotic-induced metabolic side effects: insights from receptor-binding profiles.

Abstract

Atypical antipsychotic drugs offer several notable benefits over typical antipsychotics, including greater improvement in negative symptoms, cognitive function, prevention of deterioration, and quality of life, and fewer extrapyramidal symptoms (EPS). However, concerns about EPS have been replaced by concerns about other side effects, such as weight gain, glucose dysregulation and dyslipidemia. These side effects are associated with potential long-term cardiovascular health risks, decreased medication adherence, and may eventually lead to clinical deterioration. Despite a greater understanding of the biochemical effects of these drugs in recent years, the pharmacological mechanisms underlying their various therapeutic properties and related side effects remain unclear. Besides dopamine D(2) receptor antagonism, a characteristic feature of all atypical antipsychotic drugs, these agents also bind to a range of non-dopaminergic targets, including serotonin, glutamate, histamine, alpha-adrenergic and muscarinic receptors. This review examines the potential contribution of different receptors to metabolic side effects associated with atypical antipsychotic treatment for all seven agents currently marketed in the United States (risperidone, olanzapine, quetiapine, ziprasidone, aripiprazole, paliperidone and clozapine) and another agent (bifeprunox) in clinical development at the time of this publication.

• Authors: H A Nasrallah
• Journal: Molecular psychiatry (Mol Psychiatry) Vol. 13 Issue 1 Pg. 27-35 (Jan 2008) ISSN: 1359-4184 [Print] England
• PMID: 17848919 (Publication Type: Journal Article, Research Support, Non-U.S. Gov't, Review)

Chemical References

• Antipsychotic Agents
• Blood Glucose
• Receptors, Neurotransmitter

Topics

• Animals
• Antipsychotic Agents (adverse effects, classification, metabolism)
• Blood Glucose (drug effects, metabolism)
• Humans
• Metabolic Diseases (chemically induced, metabolism)
• Receptors, Neurotransmitter (drug effects, metabolism)
• Signal Transduction (drug effects, physiology)