Regulation of angiogenesis and vascular permeability by Src family kinases: opportunities for therapeutic treatment of solid tumors.

Abstract

Aberrant expression or activation of protein tyrosine kinases, including Src and related Src family kinases, is a common occurrence in many human cancers, resulting in deregulation of expression of numerous mediators of cellular functions, including pro-angiogenic molecules. In addition, Src activation regulates vascular permeability of endothelial cells. How these processes contribute to tumor progression and metastasis are the subjects of this review. As Src-selective inhibitors have entered clinical trials for a number of solid tumors, further understanding of the roles of Src kinases in mediating tumor angiogenesis as well as modulating tumor/microenvironment interactions will provide insights into the best use of these inhibitors in treating patients afflicted with tumors in which Src is activated.

• Authors: Serk In Park, Ami N Shah, Jing Zhang, Gary E Gallick
• Journal: Expert opinion on therapeutic targets (Expert Opin Ther Targets) Vol. 11 Issue 9 Pg. 1207-17 (Sep 2007) ISSN: 1744-7631 [Electronic] England
• PMID: 17845146 (Publication Type: Journal Article, Research Support, N.I.H., Extramural, Research Support, Non-U.S. Gov't, Review)

Chemical References

• Vascular Endothelial Growth Factor A
• src-Family Kinases

Topics

• Animals
• Capillary Permeability
• Endothelial Cells (physiology)
• Humans
• Neoplasms (drug therapy, enzymology, pathology)
• Neovascularization, Pathologic
• Vascular Endothelial Growth Factor A (metabolism)
• src-Family Kinases (antagonists & inhibitors, metabolism)