[Cisplatin ototoxicity: series of cases].

Abstract

OBJECTIVE:

To evaluate the clinic and audiometric evolution of individuals who underwent chemotherapy with cisplatin.

METHODS:

Four volunteers, all women, between 38 and 69 years of age were descriptively evaluated. All did otorinolaryngoiatric exam and audiometric evaluation with tonal and speech audiometric and impedance tests before and after treatment with cisplatin. In addition, all were subjectively evaluated pre- and post-chemotherapy by a questionnaire.

RESULTS:

One volunteer did not present auditory disorders. Three volunteers presented bilateral hearing loss, mild to moderate in 6 kHz and 8 kHz frequencies, after chemotherapy with cisplatin. All volunteers who developed hearing loss after treatment also presented tinnitus.

CONCLUSION:

Since cisplatin is considered ototoxic, all individuals undergoing chemotherapy with this drug must be submitted to audiometric monitoring for early diagnosis of a hearing loss.

• Authors: Luiz Alberto Alves Mota, Marília Silvino Iglésias Melo, Maria Heloísa Pedrosa Santos, Kátia Maria Gomes de Albuquerque, Cristiana de Lima Tavares
• Journal: Revista da Associacao Medica Brasileira (1992) (Rev Assoc Med Bras (1992)) 2007 Jul-Aug Vol. 53 Issue 4 Pg. 370-3 ISSN: 0104-4230 [Print] Brazil
• Vernacular Title: Ototoxidade da cisplatina: série de casos.
• PMID: 17823744 (Publication Type: Case Reports, English Abstract, Journal Article)

Chemical References

• Antineoplastic Agents
• Cisplatin

Topics

• Adult
• Aged
• Antineoplastic Agents (adverse effects, therapeutic use)
• Audiometry
• Cisplatin (adverse effects, therapeutic use)
• Female
• Hearing Loss, Bilateral (chemically induced, physiopathology)
• Humans
• Middle Aged
• Ovarian Neoplasms (drug therapy)
• Reference Values
• Time Factors
• Tinnitus (chemically induced, physiopathology)
• Uterine Neoplasms (drug therapy)