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[Thrombolysis in deep venous thrombosis: critical review].

Abstract
Thrombolytic treatment of deep vein thrombosis remains controversial. It has never been demonstrated that the late postthrombotic syndrome may be diminished by the faster dissolution of the clots induced by streptokinase or urokinase. On the other hand are the hemorrhagic side effects associated with thrombolysis well described (lethality of 0.6%). Thrombolysis should be performed preferably under controlled conditions of a clinical study. It is indicated only in young patients with symptoms for less than 7 days of a first thrombosis. Initial results from second generation fibrinolytic substances such as rt-PA (alteplase) do not change this view drastically.
AuthorsH Bounameaux
JournalTherapeutische Umschau. Revue therapeutique (Ther Umsch) Vol. 48 Issue 10 Pg. 674-8 (Oct 1991) ISSN: 0040-5930 [Print] Switzerland
Vernacular TitleThrombolyse bei tiefer Venenthrombose: kritische Ubersicht.
PMID1780795 (Publication Type: English Abstract, Journal Article, Review)
Topics
  • Age Factors
  • Hemorrhage (chemically induced)
  • Postphlebitic Syndrome (prevention & control)
  • Thrombolytic Therapy (adverse effects)
  • Thrombosis (drug therapy)

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