Clofarabine induced durable complete remission in heavily pretreated adolescents with relapsed and refractory leukemia.

Abstract

Current treatments for relapsed/refractory leukemias are unable to achieve extended remissions in most patients even with multiagent chemotherapy. Clofarabine is a new nucleoside analog that has demonstrated clinical benefit in phase I-II studies, and is currently being studied in children and adults with leukemias and has been approved for the treatment of children with relapsed or refractory acute lymphocytic leukemia. We report the experience of three adolescents, two with acute lymphocytic leukemia in 3rd relapse and one with relapsed/refractory acute myeloid leukemia, who achieved complete remission with clofarabine. The remissions were sustained with repeated cycles of monotherapy for 47, 59, and 64 weeks, respectively.

• Authors: Peter G Steinherz, Paul A Meyers, Laurel J Steinherz, Sima Jeha
• Journal: Journal of pediatric hematology/oncology (J Pediatr Hematol Oncol) Vol. 29 Issue 9 Pg. 656-8 (Sep 2007) ISSN: 1077-4114 [Print] United States
• PMID: 17805046 (Publication Type: Case Reports, Journal Article)

Chemical References

• Adenine Nucleotides
• Arabinonucleosides
• Clofarabine

Topics

• Acute Disease
• Adenine Nucleotides (therapeutic use)
• Adolescent
• Arabinonucleosides (therapeutic use)
• Clofarabine
• Female
• Humans
• Leukemia, Myeloid (drug therapy)
• Male
• Precursor Cell Lymphoblastic Leukemia-Lymphoma (drug therapy)
• Recurrence
• Remission Induction